{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:22:02Z","timestamp":1791537722235,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In drug reaction with eosinophilia and systemic symptoms (DRESS), cutaneous tests help to identify the responsible drug. However, uncertainty may persist and drug provocation tests (DPTs) could enable contraindications for essential drugs to be avoided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the experience of DPTs in a series of DRESS patients managed in a referral centre for severe drug reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a single\u2010centre retrospective study (October 2015\u2013October 2021) of patients referred for an allergological work\u2010up after DRESS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010five patients were included (49 females, mean age 55\u2009years, 212 suspected drugs). Cutaneous tests, realised in all patients, were positive in 38, and DPTs were performed in 39 patients (65 drugs: 41 suspected and 24 alternative drugs, all with negative cutaneous tests). DPTs were performed regardless of DRESS severity or RegiSCAR score, at full dose (FD) for 40 drugs and graduated dose (from 1\/100 FD) for 25 drugs. The objective was always to avoid contra\u2010indications or to propose alternative drugs. Mild reactions occurred following challenge with 13 drugs (all suspected drugs), of which 6 could be continued. DPTs were more often positive when more drugs were suspected or reintroduced, but less often when a high\u2010notoriety drug was suspected and avoided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DPTs can be considered in DRESS by experienced teams to avoid unnecessary contraindications for essential drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70003","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T23:15:21Z","timestamp":1754003721000},"page":"404-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Drug Provocation Testing in Allergological Work\u2010Up of\n                    <scp>DRESS<\/scp>\n                    : A Retrospective Real\u2010Life Experience From a Specialist Centre"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-1241","authenticated-orcid":false,"given":"Haudrey","family":"Assier","sequence":"first","affiliation":[{"name":"Dermatology Department AP\u2010HP, Henri Mondor Hospital  Cr\u00e9teil France"},{"name":"Reference Centre for Toxic Bullous Dermatoses and Severe Drug Reactions TOXIBUL  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7303-5552","authenticated-orcid":false,"given":"Thomas","family":"Bettuzzi","sequence":"additional","affiliation":[{"name":"Dermatology Department AP\u2010HP, Henri Mondor Hospital  Cr\u00e9teil France"},{"name":"Reference Centre for Toxic Bullous Dermatoses and Severe Drug Reactions TOXIBUL  Cr\u00e9teil France"},{"name":"Univ Paris Est Cr\u00e9teil EpidermE  Cr\u00e9teil 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-2745","authenticated-orcid":false,"given":"Amandine","family":"Weill","sequence":"additional","affiliation":[{"name":"Dermatology Department AP\u2010HP, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3762-4605","authenticated-orcid":false,"given":"Olivier","family":"Gaudin","sequence":"additional","affiliation":[{"name":"Dermatology Department AP\u2010HP, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendeline","family":"Gener","sequence":"additional","affiliation":[{"name":"Dermatology Department AP\u2010HP, Henri Mondor Hospital  Cr\u00e9teil 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