{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:38:13Z","timestamp":1792456693094,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n The patch test evaluates skin erythema, infiltration, papules and vesicles following exposure to various substances, including metals, cosmetics and medicines. Accurate evaluation of these conditions requires consistent skin score assessments, precise visual grading and minimal inter\u2010expert variability.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n This study aimed to develop a skin irritation artificial intelligence model based on the\n YOLOv5x<\/jats:styled-content>\n object detection framework to automatically detect skin irritation from the patch test images for multiple test substances.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patch test images were collected with test sites marked to enable the\n YOLOv5x<\/jats:styled-content>\n algorithm to locate the samples. An expert assigned a score to each sample (0\u20134) for training and validation. The model was trained using 83\u2009629 data points. Evaluation and validation were performed with 1312 and 1536 data points, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The model achieved an overall accuracy of 0.983 at both 24 and 48\u2009h, with an\n F1<\/jats:styled-content>\n score (harmonic mean of recall and precision) of 0.982. The areas under the curve (\n AUCs<\/jats:styled-content>\n ) for scores 0, 1 and 2 were 0.914, 0.838 and 0.865, respectively. The sensitivity for a score of 0 was 0.997.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings suggest that this\n AI<\/jats:styled-content>\n model effectively supports and classifies skin irritation, thereby facilitating faster and more accurate dermatological evaluations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.70011","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:26:45Z","timestamp":1756286805000},"page":"370-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Artificial Intelligence\u2010Assisted Diagnosis of Skin Erythema in a Patch Test"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-2654","authenticated-orcid":false,"given":"Seoyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Safety and Microbiology Lab AMOREPACIFIC R&I Center Gyeonggi\u2010do South Korea"},{"name":"Department of Integrative Biotechnology Sungkyunkwan University Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsik","family":"Hwang","sequence":"additional","affiliation":[{"name":"ImagineFactory Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihyun","family":"Oh","sequence":"additional","affiliation":[{"name":"Safety and Microbiology Lab AMOREPACIFIC R&I Center Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Han","sequence":"additional","affiliation":[{"name":"Safety and Microbiology Lab AMOREPACIFIC R&I Center Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sodam","family":"Park","sequence":"additional","affiliation":[{"name":"Safety and Microbiology Lab AMOREPACIFIC R&I Center Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Safety and Microbiology Lab AMOREPACIFIC R&I Center Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goun","family":"Kim","sequence":"additional","affiliation":[{"name":"Safety and Microbiology Lab AMOREPACIFIC R&I Center Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwon","family":"Cho","sequence":"additional","affiliation":[{"name":"ImagineFactory Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Youl","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology Sungkyunkwan University Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12359"},{"key":"e_1_2_8_3_1","unstructured":"Cosmetics Europe \u201cProduct Test Guidelines for the Assessment of Human Skin Compatibility \u201d (1997)."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-36335-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb02438.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14526"},{"issue":"6","key":"e_1_2_8_8_1","first-page":"55","article-title":"Comparison of Patch Testing Results of White and Black Patients","volume":"17","author":"Nguyen L.","year":"2024","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20141"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpdig.2024.01.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10080924"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081879"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2022.100107"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0148"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14595"},{"issue":"7","key":"e_1_2_8_16_1","first-page":"920","article-title":"The Fitzpatrick Skin Type in Korean People","volume":"38","author":"Youn J. I.","year":"2000","journal-title":"Korean Journal of Dermatology"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:40:47Z","timestamp":1771231247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/cod.70011"],"URL":"https:\/\/doi.org\/10.1111\/cod.70011","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]},"assertion":[{"value":"2025-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}