{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:02:57Z","timestamp":1762315377097,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic hand eczema (CHE) has a significant negative impact on quality of life and a high disease burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the importance of skin clearance and daily time trade off (dTTO) in adult patients with CHE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with CHE from the Danish Skin Cohort were sent a digital survey regarding demographics, lifestyle factors, CHE characteristics, importance of obtaining skin clearance, and dTTO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 372 patients with current CHE, 58.1%, 26.3%, 11.0%, and 4.6% reported having mild, moderate, severe, and very severe CHE, respectively. Patients reported a median of 9 (interquartile range: [5\u201310], 9 [7\u201310], 10 [8\u201310] and 10 [9\u201310]) when asked about the importance of obtaining 50%, 75%, 90%, and 100% skin clearance, respectively (numerical rating scale from 0 [lowest] to 10 [highest]). Importance of skin clearance increased with increasing CHE severity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). One in three patients (41.2%) with either severe or very severe CHE was willing to allocate &gt;\u20091\u2009h a day to treat their CHE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Skin clearance was important among CHE patients, and patients with more severe disease were willing to allocate a substantial amount of time every day to treat their CHE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70013","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T11:14:57Z","timestamp":1756552497000},"page":"490-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Willingness and Importance of Skin Clearance for Patients With Chronic Hand Eczema"],"prefix":"10.1111","volume":"93","author":[{"given":"Maria O.","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, University of Copenhagen  Copenhagen NV Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea K.","family":"Nymand","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, University of Copenhagen  Copenhagen NV Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Meyer","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, University of Copenhagen  Copenhagen NV Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Mariel","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Dermatology Section Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schlapbach","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swen Malte","family":"John","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Osnabrueck  Osnabrueck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Molin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergy Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Division of Dermatology Queen's University  Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-300X","authenticated-orcid":false,"given":"Simon F.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, University of Copenhagen  Copenhagen NV Denmark"},{"name":"Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, University of Copenhagen  Copenhagen NV Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Egeberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, University of Copenhagen  Copenhagen NV Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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