{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:44:29Z","timestamp":1777859069245,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Benzisothiazolinone is a preservative responsible for allergic contact dermatitis, with occupational exposure being a common source of sensitisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the prevalence of positive patch test reactions to benzisothiazolinone (BIT) in Belgium, between January 2010 and December 2022, and to assess co\u2010sensitisations to other isothiazolinone derivatives in sensitised patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective monocentric study of patch test results with benzisothiazolinone (BIT) 0.1% petrolatum observed in patients attending a Belgian tertiary hospital. Prevalence, demographic data, concomitant patch test reactions, and clinical relevance were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 65 of 6128 patients (1.06%) had a positive patch test reaction to benzisothiazolinone, and its sensitisation rate increased from 0.39% in 2010 to 3.72% in 2019 (followed by a decline to 0.71% in 2022). Occupational exposure was relevant in 20% of cases, with painters and metalworkers being the most affected professions. Unexpectedly, 10.8% of BIT\u2010sensitised patients underwent patch testing due to complications following orthopaedic prosthesis implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study confirms a significant rise in BIT sensitisation over time, followed by a recent unexplained decline. Occupational exposure remains a major risk factor, but other environmental sources, including consumer products, such as leather products, should not be overlooked. The BIT sensitisation in orthopaedic prosthesis\u2010related complications requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70017","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T04:24:34Z","timestamp":1758169474000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Benzisothiazolinone Sensitization: A Retrospective Analysis From 2010 to 2022, in a Tertiary Belgian Hospital"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-1672","authenticated-orcid":false,"given":"Anne","family":"Herman","sequence":"first","affiliation":[{"name":"Department of Dermatology, Cliniques Universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"},{"name":"Institute of Experimental and Clinical Research, Pneumology, LUNS Pole Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiswendsida","family":"Sawadogo","sequence":"additional","affiliation":[{"name":"Statistical Support Unit, King Albert II Cancer and Hematology Institute Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-7939","authenticated-orcid":false,"given":"Marie","family":"Baeck","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cliniques Universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"},{"name":"Institute of Experimental and Clinical Research, Pneumology, LUNS Pole Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15267"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14300"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13968"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14641"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14255"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14818"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13956"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14523"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13273"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12642"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.29017.jdk"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1533\/9780857092939.2.97"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01278.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12700"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12322"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:24:24Z","timestamp":1777508664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/cod.70017"],"URL":"https:\/\/doi.org\/10.1111\/cod.70017","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]},"assertion":[{"value":"2025-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}