{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:18:03Z","timestamp":1789075083975,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic contact dermatitis (ACD) caused by isothiazolinones is a growing concern, particularly in consumer products. Octylisothiazolinone (OIT) is a potent sensitiser and commonly used as a preservative in rubbers, plastics and coatings, including those found in headphones. Despite increasing regulations on isothiazolinones in cosmetics, their presence in wearable devices remains under\u2010recognised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This investigation aims to identify OIT as a possible sensitiser in patients with presumed ACD due to over\u2010ear headphones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two patients with presumed ACD due to over\u2010ear headphones were patch tested at the Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital, Malm\u00f6. Patch testing included Swedish baseline series, isothiazolinone compounds, and materials from headphones. To identify potential allergens, chemical analysis of components from headphones was conducted using high\u2010performance liquid chromatography (HPLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patch testing demonstrated strong positive reactions to OIT in both cases, with additional reactions to acetone extracts of artificial leather and blue plastic foam. OIT remained positive at dilutions as low as 0.00003%. Case 1 also showed positive reactions to MI\/MCI. Chemical analysis confirmed OIT in both artificial leather (2.2\u2009mg\/g) and plastic foam (0.3\u2009mg\/g).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings contribute to the understanding of ACD by identifying OIT as a potential allergen in over\u2010ear headphones. It calls for further research into the prevalence of OIT in consumer electronics and its role in sensitisation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70028","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:15:11Z","timestamp":1757758511000},"page":"46-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Octylisothiazolinone\u2014A New Sensitizer in Over\u2010Ear Headphones"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3958-1138","authenticated-orcid":false,"given":"Blerand","family":"Berisha","sequence":"first","affiliation":[{"name":"Department of Dermatology Helsingborg Hospital  Helsingborg Sweden"},{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-8268","authenticated-orcid":false,"given":"Tina","family":"Lejding","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-030X","authenticated-orcid":false,"given":"Ola","family":"Bergendorff","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-5973","authenticated-orcid":false,"given":"Inese","family":"Hauksson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 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