{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:28:59Z","timestamp":1782401339313,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chromium (Cr) may cause contact allergy with leather being the most important exposure. To reduce contact allergy to Cr, the European Union (EU) implemented a regulation in 2015 limiting the maximum amount of hexavalent Cr in leather that comes into contact with the skin to 3\u2009mg\/kg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate prevalences, trends, and clinical and demographic characteristics of patients with contact allergy to Cr following the EU regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted. Patients aged \u2265\u200918\u2009years, who were consecutively patch tested with potassium dichromate 0.5% in petrolatum at Gentofte hospital, Denmark, from 2016 to 2024, were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 4830 patients were included. The overall prevalence of contact allergy to Cr was 2.1% with stable trends across test years. Contact allergy to Cr was associated with hand, leg and foot dermatitis, and age\u2009&gt;\u200940\u2009years. The most frequent exposure was leather shoes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Contact allergy to Cr was found to be frequent and stable. The 2015 EU regulation on the content of Cr in leather does not yet appear to significantly reduce the prevalence of contact allergy to Cr, when compared with previous Gentofte data from 2006 to 2009 (2.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.65) and from 2010 to 2013 (1.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.41).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70045","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:05:22Z","timestamp":1762225522000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trends in Contact Allergy to Chromium Following the 2015 European Union Leather Regulation"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-9198","authenticated-orcid":false,"given":"Christoffer","family":"Kursawe Larsen","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-5735","authenticated-orcid":false,"given":"Mikkel Bak","family":"Jensen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2780-3604","authenticated-orcid":false,"given":"Daniel","family":"Isufi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2010 Herlev and Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-1319","authenticated-orcid":false,"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2010 Herlev and Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2010 Herlev and Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9756-656X","authenticated-orcid":false,"given":"Jakob F. B.","family":"Schwensen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2010 Herlev and Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2011.02053.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2009.09405.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2010.01798.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1996.tb02295.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12969"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.51.6.371"},{"key":"e_1_2_10_8_1","unstructured":"https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/PDF\/?uri=OJ:JOL_2014_090_R_0001_01."},{"key":"e_1_2_10_9_1","unstructured":"https:\/\/echa.europa.eu\/de\/registry\u2010of\u2010restriction\u2010intentions\/\u2010\/dislist\/details\/0b0236e182446136."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14643"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.14255"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13181"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.12432"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14653"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.14421"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14629"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14640"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14818"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/COD.14170"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12582"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2022.105222"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42825\u2010020\u201000027\u2010y"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12581"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20101873.2003.0230.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2009.01577.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12319"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:24:14Z","timestamp":1777508654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/cod.70045"],"URL":"https:\/\/doi.org\/10.1111\/cod.70045","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}