{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:02:35Z","timestamp":1779933755120,"version":"3.53.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007761","name":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023331","name":"LEO Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The REIDAC (Spanish Registry for Research in Contact Dermatitis) conducts nationwide epidemiological surveillance of contact dermatitis in Spain. Anogenital involvement within REIDAC has not been previously studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the most common diagnoses and update relevant allergens in patients with anogenital lesions referred for patch testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed patients who underwent patch testing within REIDAC from 2019 to 2024. Patients were classified into three groups: (G1) exclusively anogenital lesions, (G2) no anogenital involvement and (G3) both anogenital and non\u2010anogenital lesions. Sensitisation and relevance were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 18\u2009291 patients, 116 (0.6%) had exclusively anogenital lesions, 17\u2009576 (96.1%) had no anogenital involvement and 599 (3.3%) had both. G1 patients were more likely to have at least one positive reaction (91.4%), a current relevant reaction (53.4%, diagnosed with allergic contact dermatitis, ACD) and to be polysensitised compared to other groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). 14.5% of anogenital ACD identified cases were not identified by the Spanish baseline series. Fragrances, preservatives, topical anaesthetics and steroids were the leading relevant allergens. Benzisothiazolinone, sodium metabisulfite and propolis emerged as new sensitisers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ACD was highly prevalent among patients with anogenital lesions referred for patch testing. The threshold for patch testing in these patients may need reconsideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70048","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T02:00:48Z","timestamp":1765332048000},"page":"272-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anogenital Contact Dermatitis in Spain: A\n                    <scp>REIDAC<\/scp>\n                    Study of Patients Undergoing Patch Testing in 2019\u20132024"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7628-3495","authenticated-orcid":false,"given":"Merc\u00e8","family":"Grau\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA  Madrid Spain"},{"name":"Research Unit Academia Espa\u00f1ola de Dermatolog\u00eda y Venereolog\u00eda (AEDV)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Mercader\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Jos\u00e9 Mar\u00eda Morales Meseguer  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute, Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Sanz\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Infanta Sof\u00eda, European University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta Zaragoza","family":"Ninet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana C\u00f3rdoba","family":"Guijarro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier Miquel","family":"Miquel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Arnau de Vilanova  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco Silvestre","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Dr Balmis, ISABIAL  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gonz\u00e1lez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Araba, Universidad del Pa\u00eds Vasco  Vitoria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada Ru\u00edz","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Serra","family":"Baldrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Germans Trias i Pujol, IGTP, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier Ortiz","family":"de Frutos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes Rodr\u00edguez","family":"Serna","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elena Gatica","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Paredes","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-3671","authenticated-orcid":false,"given":"Francisco Jos\u00e9 Navarro","family":"Trivi\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Chicharro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Andreu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araceli S\u00e1nchez","family":"Gilo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Rey Juan Carlos  M\u00f3stoles Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Juan","family":"Pereyra Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen del Roc\u00edo, Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Antonia Pastor","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Fundacion Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-0634","authenticated-orcid":false,"given":"Gemma","family":"Mel\u00e9\u2010Ninot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Sagrat Cor  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma S\u00e1nchez\u2010Pedre\u00f1o","family":"Guill\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique G\u00f3mez","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Elosua\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Munera\u2010Campos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Germans Trias i Pujol, IGTP, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-3396","authenticated-orcid":false,"given":"F\u00e1tima Tous","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Descalzo","sequence":"additional","affiliation":[{"name":"Research Unit Academia Espa\u00f1ola de Dermatolog\u00eda y Venereolog\u00eda (AEDV)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Borrego","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Insular de Gran Canaria, Universidad de Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000371"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_424_23"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crwh.2020.e00271"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2021.05.012"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000632"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae003"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3844"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321065"},{"key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2310\/6620.2010.10048","article-title":"Genital Contact Dermatitis: A Retrospective Analysis","volume":"21","author":"Bhate K.","year":"2010","journal-title":"Dermatitis: Contact, Atopic, Occupational, Drug"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468\u20103083.2000.00080.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000516"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13764"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JW9.0000000000000097"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14258"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2024.05.018"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14672"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19934"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14360"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082570"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13155"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14255"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.6.749"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14641"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14818"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14251"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745505717731011"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e31829a3216"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000603"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14626"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13968"},{"key":"e_1_2_13_34_1","unstructured":"Spain's National Institute of Statistics (INE) \u201cImmigration Flow From Abroad by Year Country of Origin and Nationality (Spanish\/Foreign) \u201d 2025 https:\/\/ine.es\/jaxiT3\/Tabla.htm?t=24295&L=1."},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461\u2010021\u201003290\u20100"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19702"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0154"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18946"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14748"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.59153\/adm.ls.001"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000011"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01964.x"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13306"},{"key":"e_1_2_13_44_1","unstructured":"G.Nyman \u201cContact Allergy to Propolis and Beeswax Occurrence Diagnostics and Chemistry \u201d 2022 https:\/\/hdl.handle.net\/2077\/71518."},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2009.01629.x"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2021.07.013"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:06:36Z","timestamp":1779930396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/cod.70048"],"URL":"https:\/\/doi.org\/10.1111\/cod.70048","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]},"assertion":[{"value":"2025-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}