{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:02:47Z","timestamp":1779933767515,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u2010NR070251"],"award-info":[{"award-number":["RS\u20102022\u2010NR070251"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102023\u2010KH141546"],"award-info":[{"award-number":["RS\u20102023\u2010KH141546"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sensitive skin syndrome (SSS) is a common disorder showing abnormal responses to stimuli, without approved treatments and unclear neuropathic mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate pregabalin efficacy in reducing SSS symptoms and identify predictors of treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic retrospective cohort of 112 clinically diagnosed SSS patients (mean age 40.5\u2009years). The primary outcome was sensitive scale\u201010 (SS\u201010) score change at 12\u2009weeks; response was defined as a\u2009\u2265\u200930% reduction. Secondary outcomes included dermatology life quality index (DLQI), hospital anxiety and depression scale (HADS), skin biophysical parameters, von Frey thresholds and facial erythema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 12\u2009weeks, 46.4% of patients responded. Most patients (86.6%) received less than 75\u2009mg\/day. Higher baseline SS\u201010 scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.5) and tingling symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.050) were associated with greater response, while discomfort was associated with non\u2010response (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). SS\u201010 scores correlated with DLQI (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.49) and total HADS (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.29). Reduced von Frey thresholds (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.28) and increased facial erythema (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.39) were observed in responders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pregabalin improved symptoms in SSS, supporting its potential role in managing neuropathic features and reinforcing the neurogenic hypothesis underlying its therapeutic mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70063","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T02:55:55Z","timestamp":1764730555000},"page":"286-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Cohort Study on the Efficacy of Pregabalin in Patients With Sensitive Skin"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-7505","authenticated-orcid":false,"given":"Han\u2010Bi","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine Hallym University, Kangnam Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-8967","authenticated-orcid":false,"given":"Min\u2010Gyu","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Computer Science Kwangwoon University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung\u2010Woo","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Computer Science Korea National Open University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Young","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Hallym University, Kangnam Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-4290","authenticated-orcid":false,"given":"So\u2010Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Hallym University, Kangnam Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2795-0140","authenticated-orcid":false,"given":"Bo\u2010Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Hallym University, Kangnam Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Hallym University, Kangnam Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-0008","authenticated-orcid":false,"given":"Hye\u2010One","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine Hallym University, Kangnam Sacred Heart Hospital  Seoul Republic of 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