{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:51:47Z","timestamp":1777949507183,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sodium lauryl sulfate (SLS) has been included as an irritant control in the baseline patch test series of the German Contact Dermatitis Research Group (DKG) for two decades, although its diagnostic value remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the strengths and limitations of SLS as an irritant control in patch testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed data from 43\u2009478 consecutive patients patch tested with 0.25% SLS aq. and 189 allergens within the IVDK network. SLS reactions were graded from 1 (weak) to 5 (strong). Associations between SLS reactivity and allergen\u2010specific responses were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 22.4% of all patients reacted positively to SLS, most with weak erythema (SLS 1). Stronger SLS reactions (SLS 2\u20135) were associated with male sex, age\u2009\u2265\u200940\u2009years, occupational dermatitis and hand dermatitis. Positive SLS reactions correlated with several allergens of high irritative potential, notably cocamidopropyl betaine, formaldehyde, sorbic acid and diphenylguanidine. In contrast, plant\u2010derived allergens showed weak or inconsistent associations. Importantly, grading SLS reactions (1\u20135) did not improve diagnostic discrimination compared to a simple positive\/negative classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While SLS can indicate skin irritability for certain allergens, it is not a universal marker. Our large\u2010scale analysis supports binary SLS classification and provides a robust evidence base for the ongoing debate on whether and how irritant controls should be used in patch testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70075","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T01:12:11Z","timestamp":1766452331000},"page":"338-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strengths and Limitations of Sodium Lauryl Sulfate as an Irritant Control in Patch Testing"],"prefix":"10.1111","volume":"94","author":[{"given":"Susann","family":"Forkel","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Department of Dermatology, Venereology and Allergology University Hospital Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke S.","family":"Matzke","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-3445","authenticated-orcid":false,"given":"Moritz M.","family":"Hollstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Kreft","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Halle (Saale) Martin Luther University Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"L\u00f6ffler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Phlebology and Allergology SLK\u2010Clinics am Gesundbrunnen  Heilbronn Germany"},{"name":"Department of Medicine Danube Private University  Krems Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Skudlik","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the University of Osnabr\u00fcck, Osnabr\u00fcck, and BG Trauma Hospital of Hamburg  Hamburg Germany"},{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Sulk","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-9862","authenticated-orcid":false,"given":"Guido","family":"Heine","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital Schleswig\u2010Holstein Campus Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus Technical University Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Uniklinikum Erlangen, Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-9865","authenticated-orcid":false,"given":"Annice","family":"Heratizadeh","sequence":"additional","affiliation":[{"name":"Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-129X","authenticated-orcid":false,"given":"Timo","family":"Buhl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14989"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18564"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12893"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06465.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4137\/EHI.S31765"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"1","article-title":"Annual Review of Cosmetic Ingredient Safety Assessments\u20142002\/2003","volume":"24","author":"Cosmetic Ingredient Review Expert Panel","year":"2005","journal-title":"International Journal of Toxicology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13956"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13971"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12504896"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1990.tb02014.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00438.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09954.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12770"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14519"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18787"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00458.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04442.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17633"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12564"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02834.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00406.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02236.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01360.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01724.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb06061.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01863.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13803"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13651"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310012584"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb01425.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02359.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:19:34Z","timestamp":1777853974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/cod.70075"],"URL":"https:\/\/doi.org\/10.1111\/cod.70075","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"2025-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}