{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:51:13Z","timestamp":1777949473219,"version":"3.51.4"},"reference-count":98,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The vast majority of allergic tattoo reactions involve red\u2010shaded tattoos without a causal explanation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine rosin oxidation products (ROPs) in pigments and tattoo inks as a hypothesised source of tattoo allergenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Content of pigment samples (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009112) and tattoo inks (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009119) was analysed using newly developed UHPLC\/PDA\/MS methods, XRD and high\u2010resolution MS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ROPs were found at varying levels in 32 pigments and 38 tattoo inks. The mean ROP level of red inks was approximately three\u2010fold higher than that of non\u2010red\u2010spectrum inks. Among 24 red\u2010spectrum inks with ROPs, azo pigments PR170, PR266, PR22, PY74 and quinacridones PR122 and PV19 were frequently identified. PR170 was present in 21 of those inks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To explain results, a manufacturing model was developed showing rosination pathways, with only some having likely allergenic outcomes. Inks whose pigments were produced with rosin incorporated and\/or irreversibly bound are the most likely to be allergenic. ROPs within those inks are believed to remain in the body after tattooing, acting as haptens. This view is consistent with biopsy reports of allergic reactions to red\u2010shaded tattoos. We propose that ROPs may be at least partially responsible for those reactions. Pending proof of this proposal, tattoo\u2010ink manufacturers might choose to avoid rosinated pigments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70076","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T04:00:57Z","timestamp":1767067257000},"page":"364-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of Rosin Oxidation Products in Pigments and Inks as a Potential Source of Tattoo Allergenicity"],"prefix":"10.1111","volume":"94","author":[{"given":"Marianita","family":"Perez\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Office of Cosmetics and Colors, Office of the Chief Scientist U.S. Food and Drug Administration  College Park Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Weisz","sequence":"additional","affiliation":[{"name":"Office of Cosmetics and Colors, Office of the Chief Scientist U.S. Food and Drug Administration  College Park Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"IPSOS 2019 https:\/\/www.ipsos.com\/en\u2010us\/news\u2010polls\/more\u2010americans\u2010have\u2010tattoos\u2010today."},{"key":"e_1_2_9_3_1","unstructured":"Pew Research Center 2023 https:\/\/www.pewresearch.org\/short\u2010reads\/2023\/08\/15\/32\u2010of\u2010americans\u2010have\u2010a\u2010tattoo\u2010including\u201022\u2010who\u2010have\u2010more\u2010than\u2010one\/."},{"key":"e_1_2_9_4_1","unstructured":"Harris Poll 2012 https:\/\/www.prnewswire.com\/news\u2010releases\/one\u2010in\u2010five\u2010us\u2010adults\u2010now\u2010has\u2010a\u2010tattoo\u2010140123523.html."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15808"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-77098-7_1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14291"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369236"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-77098-7_7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02655-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13908"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000468536"},{"key":"e_1_2_9_13_1","volume-title":"Allergy and Tattoos. 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