{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:51:47Z","timestamp":1776041507388,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273536"],"award-info":[{"award-number":["82273536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite the increasing prevalence of cosmetic\u2010related adverse reactions, their potential prognoses and associated risk factors have received limited attention within the medical community.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was conducted on 7794 cases of cosmetics\u2010related adverse reactions reported in Wuhan, China, from 2017 to 2023. Data were collected from multiple sources, including medical institutions, cosmetic manufacturers, distributors, individual consumers and regulatory agencies. Demographic characteristics, clinical diagnoses, symptom profiles and allergy histories were systematically analysed using descriptive statistics. Cases were stratified by recovery outcome into complete versus incomplete groups to identify prognostic factors. Comparative analyses were performed using \u03c72 tests, with statistically significant variables (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) further evaluated through multivariate logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). All statistical analyses were performed using SPSS version 25.0, with a significance level set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 7794 patients, the majority (76.56%) achieved complete recovery, while a substantial proportion (23.44%) experienced persistent or permanent symptoms, such as post\u2010inflammatory hyperpigmentation (PIH), atrophic scarring and other forms of skin damage. Statistical analysis identified age and a history of allergies as significant risk factors for long\u2010term skin damage. Patients under 20\u2009years of age were 2.06 times more likely to suffer persistent or permanent symptoms compared to those over 50\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). Additionally, individuals with a history of food allergy were 3.16 times more prone to long\u2010term skin damage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). A history of drug allergy also significantly increased the risk, with an OR of 1.887 (95% CI: 1.34, 2.66;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identified younger age (&lt;\u200920\u2009years) and a history of food or drug allergies as significant risk factors for long\u2010term symptoms following cosmetic adverse reactions. These insights assist dermatologists in recognising high\u2010risk individuals and guiding tailored preventive strategies. Integrating these indicators into clinical evaluation and patient counselling may enhance early intervention, ultimately reducing the likelihood of persistent or irreversible cutaneous sequelae. Overall, the findings highlight the importance of individualised risk assessment and proactive management in ensuring cosmetic safety and optimising dermatological and public health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70100","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T23:59:40Z","timestamp":1770076780000},"page":"475-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cosmetic Adverse Reactions and Prognostic Factors: A Retrospective Cohort Study in Wuhan, China"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0316-5881","authenticated-orcid":false,"given":"Ayan","family":"Hasen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengdi","family":"Yao","sequence":"additional","affiliation":[{"name":"Wuhan Center for ADR\/ADE Monitoring  Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan Center for ADR\/ADE Monitoring  Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Wuhan Center for ADR\/ADE Monitoring  Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-3110","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"591","article-title":"New Progress and Challenges in the Diagnosis and Treatment of Cosmetic Allergy\u2010Related Adverse Reactions","volume":"57","author":"Zhang C.","year":"2023","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"e_1_2_9_3_1","unstructured":"\u201cGB\/T 17149.1\u20131997 \u2010 Diagnostic Criteria and Principles of Management of Skin Diseases Induced by Cosmetics\u2014General Guideline | GlobalSpec \u201dhttps:\/\/standards.globalspec.com\/std\/14424295\/gb\u2010t\u201017149\u20101\u20101997."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0227"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.34257\/GJMRBVOL18IS2PG63"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-72451-5_83-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12358"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410025921"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13507"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13102"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.08.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.04.017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/DER.0b013e3182a5d8bc","article-title":"Allergy to Cosmetics: A Literature Review","volume":"24","author":"Alani J. 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