{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:05:22Z","timestamp":1782126322689,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limonene and linalool are widely used fragrances in cosmetic and household products. Upon air exposure, they autoxidise into potent sensitisers \u2013 hydroperoxides of limonene (Lim\u2010OOH) and linalool (Lin\u2010OOH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study is to investigate patch test reactions to Lim\u2010OOH and Lin\u2010OOH, and associated characteristics, reaction patterns, including doubtful reactions and co\u2010reactivity with other fragrance allergens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted using registry data from 6719 consecutively patch\u2010tested patients at Gentofte Hospital, Denmark (2014\u20132025). Doubtful reactions were clinically subclassified as erythematous, only (E) or infiltrated (I).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of positive patch test reactions was 1.6% for Lim\u2010OOH and 3.1% for Lin\u2010OOH. Positive Lim\u2010OOH reactions were less likely in men and in patients with atopic, occupational or hand dermatitis, whilst positive Lin\u2010OOH reactions were more likely in those &gt;\u200940\u2009years and less in atopic dermatitis. Most reactions peaked on day 3\/4 and were weakly positive. Doubtful I reactions more frequently progressed to positive than doubtful E. Co\u2010reactivity was observed between Lim\u2010OOH, Lin\u2010OOH and other fragrance allergens. Lower test concentrations reduced diagnostic sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Co\u2010reactivity with other fragrance allergens supports true allergenicity. The currently recommended patch test concentrations (0.3% Lim\u2010OOH and 1.0% Lin\u2010OOH) seem optimal and qualify for inclusion in the European baseline series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70102","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T02:10:17Z","timestamp":1770257417000},"page":"504-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ten Years of Patch Testing to Hydroperoxides of Limonene and Linalool: Prevalence, Patterns and Clinical Insights"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7252-4856","authenticated-orcid":false,"given":"Sofia","family":"Botvid","sequence":"first","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7749-0383","authenticated-orcid":false,"given":"Rebekka","family":"S\u00f8gaard","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9756-656X","authenticated-orcid":false,"given":"Jakob Ferl\u00f8v Baselius","family":"Schwensen","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen N 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