{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:19:30Z","timestamp":1790965170744,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic hand eczema (CHE) is a challenging condition with multifactorial pathomechanisms and a wide clinical polymorphism. It is often resistant to treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To clinically and etiologically investigate CHE patients using a case report form (CRF) developed for this purpose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study on adult patients affected by CHE was performed from January 2024 to May 2025 in 10 Italian dermatology clinics. Demographic data, clinical features, disease severity and duration, endogenous\/environmental risk factors, patch test results, response to past\/current treatments, and burden of disease were recorded in the dedicated CRF and analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 207 patients were enrolled in the study (mean age 41.1\u2009\u00b1\u200915.6\u2009years), 142 (68.6%) females. CHE was moderate\u2013severe in 58.9% of cases, refractory to topical potent corticosteroids in 81.4%. The etiological subtypes were irritant contact dermatitis in 52.7%, allergic contact dermatitis in 24.2%, and atopic dermatitis in 16.9%; clinical subtypes were identified in only 29.0% of patients, the most frequent ones being hyperkeratotic eczema (12.1%) and acute recurrent vesicular eczema (9.7%). The CRF proved to be easy to fill in and useful.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An accurate clinical workup can lead to CHE clinical and etiological classification in about 80% of patients and may facilitate tailored treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70105","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T22:45:07Z","timestamp":1771195507000},"page":"662-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010Life Workup of Chronic Hand Eczema Using a Dedicated Case Report Form: A SIDAPA Multicentre Study"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-4425","authenticated-orcid":false,"given":"Rosella","family":"Gallo","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences University of Genoa and Ospedale Policlinico San Martino, IRCCS  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-8496","authenticated-orcid":false,"given":"Fabrizio","family":"Guarneri","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-4278","authenticated-orcid":false,"given":"Katharina","family":"Hansel","sequence":"additional","affiliation":[{"name":"Dermatology Section, Department of Medicine and Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-8141","authenticated-orcid":false,"given":"Luca","family":"Stingeni","sequence":"additional","affiliation":[{"name":"Dermatology Section, Department of Medicine and Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3309-8190","authenticated-orcid":false,"given":"Maddalena","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8661-2822","authenticated-orcid":false,"given":"Cataldo","family":"Patruno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences Vincenzo Tiberio University of Molise  Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2105-6217","authenticated-orcid":false,"given":"Monica","family":"Corazza","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Infectious Diseases, Department of Medical Sciences University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-9691","authenticated-orcid":false,"given":"Alessandro","family":"Borghi","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Infectious Diseases, Department of Medical Sciences University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5469-4517","authenticated-orcid":false,"given":"Ilaria","family":"Trave","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences University of Genoa, IRCCS, Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0815-172X","authenticated-orcid":false,"given":"Emanuela","family":"Martina","sequence":"additional","affiliation":[{"name":"Dermatology Unit Ospedale Carlo Urbani  Jesi Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2243-0293","authenticated-orcid":false,"given":"Maria Michela","family":"Lauriola","sequence":"additional","affiliation":[{"name":"Istituti Ospedalieri Bergamaschi, Policlinico San Marco, Dermatology Unit Zingonia Osio Sotto  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2814-5629","authenticated-orcid":false,"given":"Rosanna Rita","family":"Satta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6196-9788","authenticated-orcid":false,"given":"Caterina","family":"Foti","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Precision and Regenerative Medicine and Jonian Area University Aldo Moro of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-9722","authenticated-orcid":false,"given":"Paolo","family":"Romita","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Precision and Regenerative Medicine and Jonian Area University Aldo Moro of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5492-3033","authenticated-orcid":false,"given":"Roberta","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-1366","authenticated-orcid":false,"given":"Silvia Mariel","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"SIDAPA CHE Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01810-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-024-00890-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v105.42596"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13804"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14407"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12130"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16147"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14205"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v102.360"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14035"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14775"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19742"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S292504"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01027-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.03.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12840"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-025-01365-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2024.0186"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-025-03947-z"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03438-7"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.04.027"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2521"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06305.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-02818-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07565.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1246"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21037"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2784-8671.24.07733-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-0488.19.06301-6"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12819"},{"issue":"6","key":"e_1_2_9_33_1","first-page":"682","article-title":"Translation and Pre\u2010Validation of the Quality of Life in Hand Eczema Questionnaire (QOLHEQ)","volume":"159","author":"Gallo R.","year":"2024","journal-title":"Italian Journal of Dermatology and Venereology"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01911.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13220"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-024-01312-y"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14732"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf020"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v101.432"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13113"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13041"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07694.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v103.5383"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14684"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15660"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09139.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01630.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2024.10.068"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14367"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.04.052"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13371"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2024.10.3396"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18923"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754231188325"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21604"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00341-1"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:41:37Z","timestamp":1777956097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/cod.70105"],"URL":"https:\/\/doi.org\/10.1111\/cod.70105","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}