{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:02:08Z","timestamp":1777510928742,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fragrance allergy is difficult to define, with thousands of known fragrance\u2010related compounds. Whether certain botanicals should be considered \u2018fragrance\u2019 and whether fragrance\u2010allergic patients should avoid these ingredients remains unclear, with minimal published data on the topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether there is cross\u2010reactivity between fragrance and various botanicals commonly found in personal\u2010care products, such as aloe, coconut oil and shea butter, among others.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of fragrance\u2010allergic patients was identified using data from 2038 patients patch\u2010tested at a tertiary referral centre from 2020\u20132024. Cross\u2010reactivity rates to botanicals commonly found in personal\u2010care products were calculated, and statistical significance was determined using Fisher's exact test. Cross\u2010reactivity was defined as &gt;\u200910% reaction incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients with fragrance allergy, there was no significant cross\u2010reactivity to any of the investigated botanical compounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The low concomitant rates of reaction between fragrance and the investigated substances suggest that patients allergic to fragrance do not need to avoid certain common botanicals. Many products contain these compounds, including ones marked as \u2018fragrance\u2010free\u2019. Dermatologists can safely reassure fragrance\u2010allergic patients of the safety of many botanicals commonly used in personal\u2010care products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70107","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:19:32Z","timestamp":1770448772000},"page":"488-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["To Avoid or Not to Avoid: Cross\u2010Reactivity Between Fragrance and Common Botanicals"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1758-8003","authenticated-orcid":false,"given":"Sarah","family":"Karels","sequence":"first","affiliation":[{"name":"Department of Dermatology Park Nicollet Contact Dermatitis Clinic  Minneapolis Minnesota USA"},{"name":"University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brailyn","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Dermatology Park Nicollet Contact Dermatitis Clinic  Minneapolis Minnesota USA"},{"name":"University of North Dakota School of Medicine  Grand Forks North Dakota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Hylwa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Park Nicollet Contact Dermatitis Clinic  Minneapolis Minnesota USA"},{"name":"Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solveig","family":"Ophaug","sequence":"additional","affiliation":[{"name":"Department of Dermatology Park Nicollet Contact Dermatitis Clinic  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Park Nicollet Contact Dermatitis Clinic  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Neeley","sequence":"additional","affiliation":[{"name":"Department of Dermatology Park Nicollet Contact Dermatitis Clinic  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12117"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000661"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0109"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000186"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.04009"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2007.01118.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20101873.2005.00713.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12665"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12233"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12292"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000228"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12080"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27123735"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13381"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.10.101"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100536.2002.460414.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12108"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102359\u20108097"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c04277"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27123909"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13992"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1996.tb02126.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20101873.2006.0847e.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/HM9.0000000000000103"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12725"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr10010056"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2008.02983.x"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12585"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12081626"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14478"},{"key":"e_1_2_12_32_1","volume-title":"Manual of Contact Dermatitis","author":"Fregert S.","year":"1981"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000798"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000463"},{"key":"e_1_2_12_35_1","unstructured":"Regulation 2023\/1545 \u201cCommission Regulation (EU) 2023\/1545 of 26 July 2023 Amending Regulation (EC) No 1223\/2009 of the European Parliament and of the Council as Regards Labelling of Fragrance Allergens in Cosmetic Products \u201dhttps:\/\/eur\u2010lex.europa.eu\/eli\/reg\/2023\/1545\/oj\/eng."}],"container-title":["Contact 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