{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:09:09Z","timestamp":1790219349324,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006286","name":"Kongelig Hofbuntmager Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fragrance allergens are a leading cause of contact allergy (CA). Linalool, common in cosmetics and household products, forms sensitising hydroperoxides (Lin\u2010OOH) upon air exposure. Lin\u2010OOH is linked to a high prevalence (3.9%\u201311.7%) of positive patch test results, but often gives rise to doubtful or irritant reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To reassess patch test concentrations of Lin\u2010OOH, determine elicitation threshold under repeated exposure, and explore associated immunological responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patch testing was followed by a twice daily, 21\u2009days repeated open application test (ROAT) using a Lin\u2010OOH\u2010containing simulated perfume at three different concentrations (blinded to the participants and the investigators). Twelve sensitised individuals with CA to Lin\u2010OOH and 20 healthy controls were included. Skin biopsies from a subset were analysed via RT\u2010qPCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lin\u2010OOH 1.0% was the most reliable patch test concentration to confirm CA in our patient cohort. Positive ROAT reactions occurred in 4\/12 (33%) patients at 0.163% Lin\u2010OOH (1630\u2009ppm), 2\/12 (17%) at 0.054% (538\u2009ppm) and 1\/12 (8%) at 0.018% (179\u2009ppm); none in controls. Gene expression analysis showed upregulation of IL1 family members (IL1\u03b2 and IL1RN), type 2 immune response (IL4 and GATA3) and chemokines (CCL22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lin\u2010OOH elicited dose\u2010dependent reactions in sensitised individuals during both patch testing and simulated use (ROAT). Molecular profiling of biopsy samples confirmed activation of immune pathways consistent with CA to fragrances following patch testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70119","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:51:18Z","timestamp":1771545078000},"page":"652-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Repeated Exposure to Hydroperoxides of Linalool Induces Immunologically Verified Allergic Contact Dermatitis"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7252-4856","authenticated-orcid":false,"given":"Sofia","family":"Botvid","sequence":"first","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels H\u00f8jsager","family":"Bennike","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5878-0971","authenticated-orcid":false,"given":"Alexandra T.","family":"Seibel","sequence":"additional","affiliation":[{"name":"LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-0326","authenticated-orcid":false,"given":"Helen","family":"Vaher","sequence":"additional","affiliation":[{"name":"LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-6229","authenticated-orcid":false,"given":"Charlotte Menn\u00e9","family":"Bonefeld","sequence":"additional","affiliation":[{"name":"LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron I.","family":"Moore","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Trinity Biomedical Sciences Institute, Trinity College Dublin  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-4944","authenticated-orcid":false,"given":"Niamh","family":"O'Boyle","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Trinity Biomedical Sciences Institute, Trinity College Dublin  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Hagvall","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","unstructured":"W.Uter A.Bauer A.Belloni Fortina et\u00a0al. \u201cPatch Test Results With the European Baseline Series and Additions Thereof in the ESSCA Network 2015\u20132018 \u201d84 no.2(2021):109\u2013120 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