{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:16:00Z","timestamp":1783016160815,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SERB\/F\/213\/2019\u20102020"],"award-info":[{"award-number":["SERB\/F\/213\/2019\u20102020"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Parthenium dermatitis is a chronic relapsing allergic Contact Dermatitis caused by\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Parthenium hysterophorus<\/jats:italic>\n                      <\/jats:styled-content>\n                      presenting therapeutic challenges. Cyclosporine, a calcineurin inhibitor with rapid anti\u2010inflammatory effects, may be useful for short\u2010term disease control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness and safety of cyclosporine in parthenium dermatitis and correlate treatment response with inflammatory cytokine levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ths prospective, open\u2010label study enrolled 50 patch test\u2013positive patients treated with cyclosporine (2.5\u2009mg\/kg\/day) for up to 12\u2009weeks. Clinical severity scores (CSS) and adverse effects were monitored. Serum cytokines (TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , IL\u20106, IL\u201017, IL\u201010) were assessed pre\u2010 and post\u2010treatment in 27 patients. Patients were followed monthly for 3\u2009months post\u2010treatment to assess relapse.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 48 ptients who were evaluated, 35 (72.9%) achieved complete remission (CSS\u2009=\u20090), and 7 (14.6%) showed significant improvement. IL\u20106 levels decreased significantly post\u2010treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003), while TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      and IL\u201017 showed a non\u2010significant decline. IL\u201010 levels remained unchanged. Relapse occurred in 69% of patients within a mean of 2.9\u2009weeks after treatment cessation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cyclosporine is an effective short\u2010term therapy for parthenium dermatitis, but relapse is frequent after abrupt withdrawal. Tapering or transitioning to steroid\u2010sparing agents may enhance long\u2010term control. Reduction in IL\u20106 highlights its role in disease pathogenesis and response to immunosuppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70133","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:56:22Z","timestamp":1775548582000},"page":"207-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Cyclosporine in Parthenium Dermatitis: A Prospective Study to Evaluate Treatment Outcomes and Inflammatory Cytokine Levels"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8178-6388","authenticated-orcid":false,"given":"Kaushal","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Biochemistry All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4604-3917","authenticated-orcid":false,"given":"Neetu","family":"Bhari","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braj Mohan R. N.","family":"Kutar","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.440107-16.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.100522"},{"key":"e_1_2_13_4_1","first-page":"309","article-title":"Evaluation on Azathioprine in the Treatment of Parthenium Dermatitis","volume":"67","author":"Khurana S.","year":"2001","journal-title":"Indian Journal of Dermatology, Venereology and Leprology"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13697"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.198037"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_135_21"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_189_22"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01208.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015559850135814"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.049"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90134-B"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb13111.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14406"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12701"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14234"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14204"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01693.x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10248.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:19:27Z","timestamp":1783012767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/cod.70133"],"URL":"https:\/\/doi.org\/10.1111\/cod.70133","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}