{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:49:29Z","timestamp":1781653769350,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies investigating gold allergy have used gold thiosulphate (GCST) rather than pure gold, reporting an incidence up to 30%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>As it is unclear whether these reactions are due to ions from pure gold or solely to ions from gold salts, this study aimed to determine whether an allergy to pure gold itself exists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Sixty patients with cutaneous allergic reactions participated in the study. A standard epicutaneous test was performed with both a test chamber with pure gold micro\u2010particles (20\u201340\u2009\u03bcm in diameter) in petrolatum and the GST, which is part of the standard \u2018Thin Layer Rapid Use Epicutaneous Patch (T.R.U.E.) Test\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>None of the patients reacted to the gold micro\u2010particles, while thirteen reacted to GST.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study did not elicit any allergic reaction to the gold micro\u2010particles. These findings confirmed clinical observations that allergy to gold salts is quite common but suggest that pure metallic gold is not an allergen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70140","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:11:36Z","timestamp":1774422696000},"page":"51-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is There an Allergy to Pure Metallic Gold Micro\u2010Particles?\u2014An Epicutaneous Study of Gold Micro\u2010Particles, Gold Thiosulphate, and Placebo"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-352X","authenticated-orcid":false,"given":"Sten","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-1390","authenticated-orcid":false,"given":"Peter","family":"Bjerring","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13827"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000477"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2008.01401.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2010.01671.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14707"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1mt00062d"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.221150"},{"key":"e_1_2_9_10_1","first-page":"207","article-title":"Gold Bead Implants","volume":"4","author":"Durkes T.","year":"1992","journal-title":"Problemy Veterinarnoi Meditsiny"},{"key":"e_1_2_9_11_1","unstructured":"J.Klitsgaard \u201cGold Implants \u2010 Practical Experiences With 400 Hip Dysplasia Cases in the Dog \u201dinProceedings of the International Veterinary Acupuncture Society Proceedings 22nd International Congress Spiez Schweiz (1996) 1\u20135."},{"key":"e_1_2_9_12_1","unstructured":"S.Thoresen \u201cA \u2018New\u2019 Method of Placing Gold Implants to Treat Hip Dysplasia in the Dog. Description and Evaluation of 50 Cases 1990 \u201dinProceedings of the International Veterinary Acupuncture Society Proceedings 22nd International Congress Spiez Schweiz (1996) 1\u20137."},{"key":"e_1_2_9_13_1","first-page":"47","article-title":"\u00dcber Die Implantation von Goldpartikeln Zur Therapeutischen Beeinflussung von Schmerzhaften Prozessen Im H\u00fcftgelenksbereich von Hunden \u2013 Dargestellt an Drei Fallbeispielen","volume":"84","author":"Kothbauer O.","year":"1997","journal-title":"Wiener Tier\u00e4rztliche Monatsschrift"},{"key":"e_1_2_9_14_1","first-page":"17","article-title":"Efficacy of Gold Bead Acupuncture Treatment of Chronic Hip, Elbow and Spine Pain in 79 Dogs Following Unsuccessful Conventional Treatments","volume":"15","author":"Bartholom\u00e9 M.","year":"2020","journal-title":"American Journal of Traditional Chinese Veterinary Medicine"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.149.15.452"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1632724"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.158.21.722"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010008\u20100918\u20109"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2010.0775"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1909"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201077760\u20105"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010024\u201007321\u20104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15093355"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115481"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1088878"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2021.02.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S279094"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv\u20102025\u2010d6dw4"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.104"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1985.tb02292.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814\u2010019\u20100423\u20108"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14027"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13105"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418\u2010002\u20100400\u20108"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.07.020"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000609"},{"key":"e_1_2_9_37_1","first-page":"21","article-title":"Contact Allergy to Gold and Its Alloys. 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