{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:09:42Z","timestamp":1780646982006,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isothiazolinones are widely used as preservatives in both cosmetic and non\u2010cosmetic products. Sensitisation to isothiazolinones other than chloromethylisothiazolinone\/methylisothiazolinone (CMIT\/MIT), present in the baseline series, is increasing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the prevalence of sensitisation to benzisothiazolinone (BIT) in comparison to CMIT\/MIT and to develop a product\u2010independent analysis method of isothiazolinones for laboratories with basic instrumentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patch testing with BIT and CMIT\/MIT was performed in 803 consecutively tested dermatitis patients. A simple and general analysis method for isothiazolinones was developed for HPLC\u2010UV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Investigation of 14 products labelled to contain BIT and\/or CMIT\/MIT (cosmetic and non\u2010cosmetic) showed concentrations of BIT in non\u2010cosmetic products of up to 272\u2009ppm. Maximum detected concentrations of CMIT and MIT were 0.3 and 1.5\u2009ppm, respectively. Dichloroctylisothiazolinone and MIT were detected in an unlabelled hobby paint. BIT was a significantly more common cause of sensitisation than CMIT\/MIT, at 7.7% and 5.2%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results confirm previous reports indicating that sensitisation to BIT is increasing in dermatitis patients in western Sweden. Analysis of products showed that concentrations of BIT can be several orders of magnitude higher than those of CMIT\/MIT in products to which skin contact can be frequent and long lasting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70147","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:20:13Z","timestamp":1774592413000},"page":"33-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Generic Analysis Method for Isothiazolinones in Consumer Products Prompted by Increased Sensitisation to Benzisothiazolinone"],"prefix":"10.1111","volume":"95","author":[{"given":"Anne","family":"Farbrot","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Kentson","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Koca","family":"Akdeve","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Sahlgrenska University Hospital  Gothenburg 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