{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:14:20Z","timestamp":1791396860327,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100022654","name":"HudFonden","doi-asserted-by":"publisher","award":["3037\/2020"],"award-info":[{"award-number":["3037\/2020"]}],"id":[{"id":"10.13039\/501100022654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022654","name":"HudFonden","doi-asserted-by":"publisher","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100022654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022654","name":"HudFonden","doi-asserted-by":"publisher","award":["2906\/2019"],"award-info":[{"award-number":["2906\/2019"]}],"id":[{"id":"10.13039\/501100022654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009487","name":"Stiftelsen Forska Utan Djurf\u00f6rs\u00f6k","doi-asserted-by":"publisher","award":["F2022"],"award-info":[{"award-number":["F2022"]}],"id":[{"id":"10.13039\/100009487","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limonene and linalool are fragrance terpenes that undergo autoxidation to sensitizing hydroperoxides. This study assessed the penetration of limonene hydroperoxide and linalool hydroperoxide from patch test preparations in ex\u00a0vivo human skin samples, alongside analysing the effects of the patch test preparations on the composition of skin lipids, using Time\u2010of\u2010Flight Secondary Ion Mass Spectrometry (ToF\u2010SIMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NativeSkin Access human skin biopsies were treated with commercially available patch test preparations \u2018hydroperoxides of linalool (1.0%)\u2019 or \u2018hydroperoxides of limonene (0.3%)\u2019. ToF\u2010SIMS analysis was performed to assess skin penetration of limonene hydroperoxide and linalool hydroperoxide and assess changes in endogenous lipids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ToF\u2010SIMS analysis showed that limonene hydroperoxide and linalool hydroperoxide remain mainly confined to the stratum corneum. Multivariate analysis indicated that the chemical composition of the stratum corneum differed in the patch test exposed skin in comparison to control samples. There were significant changes in the intensity of several lipid species upon exposure to the patch test exposed skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Absorption of limonene hydroperoxide and linalool hydroperoxide occurs from patch test preparations. Skin exposure to these preparations can alter the skin lipidome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70157","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:10:16Z","timestamp":1776906616000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Absorption and Effects of Patch Test Preparations of Hydroperoxides of Limonene and Hydroperoxides of Linalool in Human Ex\u00a0Vivo Skin"],"prefix":"10.1111","volume":"95","author":[{"given":"Aoife","family":"Clancy","sequence":"first","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Hagvall","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Occupational and Environmental Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Malmberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Chalmers University of Technology  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-4944","authenticated-orcid":false,"given":"Niamh M.","family":"O'Boyle","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-68617-2_14"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"583","article-title":"Contact Sensitization to Fragrance Allergen: A 5\u2010Year Review in the Department of Dermatology, Hospital Kuala Lumpur","volume":"78","author":"Tai V.","year":"2023","journal-title":"Medical Journal of Malaysia"},{"key":"e_1_2_11_4_1","unstructured":"International Fragrance Association What is a Fragrance?(2025) https:\/\/ifrafragrance.org\/fragrance\u2010and\u2010you\/what\u2010is\u2010a\u2010fragrance."},{"key":"e_1_2_11_5_1","unstructured":"European Union \u201cOpinion on Fragrance Allergens in Cosmetic Products \u201d SCCS\/1459\/11(2012)."},{"key":"e_1_2_11_6_1","first-page":"1193","article-title":"Limonene \u2010 a Review: Biosynthetic, Ecological and Pharmacological 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