{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:41:06Z","timestamp":1786113666736,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dyshidrotic eczema (DE), also termed acute and recurrent vesicular dermatitis, is a vesicular clinical pattern of hand eczema (HE) with heterogeneous aetiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterise the clinical\u2010allergological profile of patients with DE and to compare it with non\u2010DE HE subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicentre, retrospective, observational study was conducted using data from the Spanish Contact Dermatitis Registry (2019\u20132024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 4378 patients with HE, 559 were diagnosed with DE. A longer median disease duration (24 vs. 14\u2009months) and more frequent palmoplantar involvement (16% vs. 7%) were observed in DE compared with non\u2010DE HE. At least one positive patch test was identified in 43% of DE versus 52% in non\u2010DE HE. Although overall sensitisation patterns were largely comparable, DE showed lower sensitisation rates to 2\u2010HEMA, carba mix and thiuram mix. Occupational factors were less frequently implicated in DE (9% vs. 29%) compared with non\u2010DE HE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite a high overall frequency of contact allergen sensitisation, the pattern of findings suggests that the dyshidrotic phenotype may follow a clinical course less dependent on external or occupational triggers, pointing towards a relatively greater contribution of endogenous factors compared with other HE subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70184","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:55:04Z","timestamp":1779065704000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological, Clinical and Allergic Profile of Patients With Dyshidrotic Eczema (Acute and Recurrent Vesicular Dermatitis): Evaluation of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy (\n                    <scp>REIDAC<\/scp>\n                    )"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-6405","authenticated-orcid":false,"given":"Araceli","family":"S\u00e1nchez\u2010Gilo","sequence":"first","affiliation":[{"name":"Escuela Internacional de Doctorado, Rey Juan Carlos University  Madrid Spain"},{"name":"Department of Dermatology Hospital Universitario Rey Juan Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"G\u00f3mez de la Fuente","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Silvestre\u2010Salvador","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Dr Balmis. ISABIAL  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-9725","authenticated-orcid":false,"given":"Pedro","family":"Mercader\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Jos\u00e9 Mar\u00eda Morales Meseguer  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Sanz\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Infanta Sof\u00eda  Madrid Spain"},{"name":"Departamento de Medicina Facultad de Medicina Salud y Deporte, Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Zaragoza\u2010Ninet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"C\u00f3rdoba\u2010Guijarro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Miquel\u2010Miquel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Arnau de Vilanova de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gonz\u00e1lez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Araba, Universidad del Pa\u00eds Vasco  Vitoria\u2010Gasteiz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Ruiz\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Le\u00f3n (CAULE)  Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Serra\u2010Baldrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Carrascosa\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Germans Trias i Pujol  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Ortiz de Frutos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rodr\u00edguez\u2010Serna","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-5834","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"Gatica\u2010Ortega","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7100-6652","authenticated-orcid":false,"given":"Carmen","family":"Paredes\u2010Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario de Santiago  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-3671","authenticated-orcid":false,"given":"Francisco J.","family":"Navarro\u2010Trivi\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario San Cecilio  Granada 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Associated With Palmoplantar or Plantar Pompholyx: A Case\u2013Control Study","volume":"133","author":"Pitch\u00e9 P.","year":"2006","journal-title":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie"},{"issue":"2","key":"e_1_2_10_27_1","first-page":"63","article-title":"Atopy, Nickel Sensitivity, Occupation, and Clinical Patterns in Different Types of Hand Dermatitis","volume":"14","author":"Magina S.","year":"2003","journal-title":"American Journal of Contact Dermatitis"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0379.2009.07061_supp.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14016"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1992.tb03813.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2024.08.010"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14520"}],"container-title":["Contact 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