{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:41:31Z","timestamp":1786113691588,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic hand eczema (CHE) is a common dermatitis with morphological and aetiological heterogeneity. Allergic contact dermatitis (ACD) is a major aetiology, and patch testing (PT) is essential to characterize CHE and guide its treatment and prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Determine the prevalence of ACD in CHE patients, describe relevant allergens, and identify differences in atopic and occupational settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicentric retrospective observational study, based on PT results of CHE patients evaluated between 2021 and 2023, in Portuguese dermatology departments, comparing atopic dermatitis and non\u2010atopic and occupational and non\u2010occupational groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1267 patients (391 males\/876 females) with CHE, representing 43% of all patients tested, 57% had at least one positive PT reaction, 41% of which were currently relevant. The most common allergens included metals, preservatives, fragrances, rubber constituents and 2\u2010hydroxyethyl methacrylate. The occupational group revealed higher relevance rates for metals and benzisothiazolinone, whereas in the atopic dermatitis group, methylisothiazolinone and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Myroxylon pereirae<\/jats:italic>\n                      <\/jats:styled-content>\n                      were considered more frequently relevant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CHE patients present a high sensitization rate and ACD is a main aetiology. Methylisothiazolinone and 2\u2010hydroxyethyl methacrylate are confirmed as emergent allergens. The higher relevance rate of metals and benzisothiazolinone in the occupational group reinforces the importance of PT in the occupational setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70186","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:20:43Z","timestamp":1779078043000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patch Testing in Chronic Hand Eczema: A Multicentre Study in Portugal"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-5637","authenticated-orcid":false,"given":"Andr\u00e9 Apar\u00edcio","family":"Martins","sequence":"first","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Almeida","sequence":"additional","affiliation":[{"name":"Occupational Health Department Hospital Rainha Santa Isabel, Unidade Local de Sa\u00fade M\u00e9dio Tejo  Torres Novas Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Lobo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital de Santo Ant\u00f3nio, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Brasileiro","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital de Santo Ant\u00f3nio dos Capuchos, Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9  Lisboa Portugal"},{"name":"NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, NMS, FCM Universidade Nova de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Unidade Local de Sa\u00fade de Coimbra  Coimbra Portugal"},{"name":"Dermatology, Faculdade de Medicina Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Grupo Portugu\u00eas de Estudo das Dermites de Contacto 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