{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:32:06Z","timestamp":1791426726159,"version":"4.3.3"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002784","name":"Canada Excellence Research Chairs, Government of Canada","doi-asserted-by":"publisher","award":["CRC\u20102024\u201000200"],"award-info":[{"award-number":["CRC\u20102024\u201000200"]}],"id":[{"id":"10.13039\/501100002784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Contact allergy to gold is frequently observed in patch testing, although with low clinical relevance. Nickel allergy, in contrast, is common, clinically relevant, and nickel release from jewellery remains a regulatory concern. Standardised artificial sweat tests show no detectable gold release from gold\u2010containing jewellery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess surface composition and the release of nickel and gold from gold\u2010plated earrings under clinically relevant biochemical conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten pairs of low\u2010cost gold\u2010plated earrings were analysed by scanning electron microscopy (SEM) with energy\u2010dispersive spectroscopy (EDS) and X\u2010ray fluorescence. Metal release was assessed using a cysteine\u2010modified artificial sweat solution at 30\u00b0C for 168\u2009h. Gold and nickel concentrations were quantified by inductively coupled plasma mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nickel release was detected in 10\/10 earrings (median: 2.1\u2009\u03bcg\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , range: 0.00032\u201310.0) frequently exceeding the EU regulatory limit. Gold release was detected in 4\/10 earrings (median: 0.00092\u2009\u03bcg\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , range: 0.00041\u20130.21). Gold was identified by cross\u2010sectional SEM\/EDS in a subset of components (6\/20) but was not detected by top\u2010down XRF analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nickel release from gold\u2010plated earrings was widespread and often exceeded regulatory limits, indicating that gold plating does not reliably prevent nickel exposure. Gold release occurred in some earrings, but the clinical relevance remains uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70187","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:29:22Z","timestamp":1779078562000},"page":"380-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gold and Nickel Release From Gold\u2010Plated Earrings Under Cysteine\u2010Modified Artificial Sweat Conditions"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-5735","authenticated-orcid":false,"given":"Mikkel Bak","family":"Jensen","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-7826","authenticated-orcid":false,"given":"Malin Glindvad","family":"Ahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3253-0351","authenticated-orcid":false,"given":"Morten S.","family":"Jellesen","sequence":"additional","affiliation":[{"name":"Department of Civil and Mechanical Engineering Technical University of Denmark, Kgs  Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-9381","authenticated-orcid":false,"given":"Saman","family":"Nikpour","sequence":"additional","affiliation":[{"name":"Department of Chemistry Western University (The University of Western Ontario)  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-6443","authenticated-orcid":false,"given":"Ren\u00e9 Daniel","family":"P\u00fctz","sequence":"additional","affiliation":[{"name":"Department of Chemistry Western University (The University of Western Ontario)  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2145-3650","authenticated-orcid":false,"given":"Yolanda","family":"Hedberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry Western University (The University of Western Ontario)  London Ontario Canada"},{"name":"Surface Science Western, The University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital  Hellerup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14707"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000477"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.29017.jdk"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1998.tb05942.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101541"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.09.021"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/J.1600\u20100536.2000.043006344.X"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14837"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.8b00537"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/215416a0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.2.248"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppsc.202400230"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107235"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1116\/6.0000910"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12775"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2010.01709.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12782"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb07601.x"}],"container-title":["Contact 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