{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:12:37Z","timestamp":1788858757676,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Contact allergy to methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) remains common in the EU despite regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the extent of use of MCI\/MI and MI in cosmetic products on the Danish market, identify product categories involved and evaluate compliance of rinse\u2010off products with the 15\u2009ppm limit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Products listing MCI\/MI or MI were identified through Kemiluppen, a Danish database of marketed cosmetics. Thirty products (16 shampoos and 14 liquid soaps) were examined using liquid chromatography\u2013tandem mass spectrometry: 25 labelled as containing MCI\/MI or MI, 5 unlabelled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 257 cosmetic products containing MCI\/MI or MI were identified, primarily shampoos (127), conditioners (98) and liquid soaps (8). Chemical analysis showed that 2 of 25 labelled products (8%) exceeded the 15\u2009ppm limit, and 4 products did not meet the required 3:1 MCI\/MI ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCI\/MI is used infrequently in cosmetic products. All, except two products complied with the limit in the regulation. Given the continued occurrence of contact allergy, this indicates that the limit (15\u2009ppm) may be too high to be sufficiently protective. Further investigation into MCI\/MI use in cosmetic products is warranted, alongside more proactive risk assessment and management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70202","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:46:19Z","timestamp":1781610379000},"page":"405-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Methylchloroisothiazolinone and Methylisothiazolinone 10\u2009Years After Regulation: A Case Story of Liquid Soaps and Shampoos"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7185-2042","authenticated-orcid":false,"given":"Mathias Krogh","family":"Pedersen","sequence":"first","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9756-656X","authenticated-orcid":false,"given":"Jakob Ferl\u00f8v Baselius","family":"Schwensen","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3504-2473","authenticated-orcid":false,"given":"Jose Hern\u00e1n","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Section of Occupational Toxicology National Institute of Occupational Health  Oslo Norway"},{"name":"Department of Dermatology and Venereology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel S\u00f8gaard","family":"Kirkeby","sequence":"additional","affiliation":[{"name":"The Danish Consumer Council THINK Chemicals (Forbrugerr\u00e5det TAENK Kemi)  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"The Danish Consumer Council THINK Chemicals (Forbrugerr\u00e5det TAENK Kemi)  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Mollerup","sequence":"additional","affiliation":[{"name":"Section of Occupational Toxicology National Institute of Occupational Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Selvestrel","sequence":"additional","affiliation":[{"name":"Environmental Sustainability for Industrial and Health Systems Unit, Environmental Health Department Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"},{"name":"Division of Toxicology Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Rud\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Environmental Science Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Wilks","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology Copenhagen University Hospital Herlev\u2010Gentofte, Gentofte Hospital  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2008.01501.x"},{"key":"e_1_2_10_3_1","unstructured":"European Union \u201cEleventh Commission Directive 89\/174\/EEC of 21 February 1989 Adapting to Technical Progress Annexes II III IV V VI and VII to Council Directive 76\/768\/EEC on the Approximation of the Laws of the Member States Relating to Cosmetic Products \u201daccessed 7 January 2026 https:\/\/eur\u2010lex.europa.eu\/eli\/dir\/1989\/174\/oj\/eng."},{"key":"e_1_2_10_4_1","unstructured":"European Union \u201cThe Commission of the European Communities. 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