{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:12:34Z","timestamp":1788858754341,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fragrance and preservative chemicals in cosmetic and household cleaning products are recognised causes of allergic contact dermatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify fragrance and preservative ingredients with potential contact allergenicity in Turkish market products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Labels of 245 products, including predominantly rinse\u2010off cosmetic products and household cleaning products obtained during on\u2010site visits to chain supermarkets were reviewed. Fragrance and preservative ingredients were scored (0\u20132) for reported allergen potential and summed as an \u2018allergen load\u2019 per product.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cosmetics had significantly higher number of fragrance ingredients and fragrance loads than cleaning products. The most frequent fragrance substances were linalool, limonene and hexyl cinnamal. Paediatric products contained fewer fragrance and preservative ingredients than adult products. Sodium benzoate, methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) were the most common preservatives; laundry detergents had the highest preservative load, wet wipes and surface cleaners the lowest. Anti\u2010dandruff shampoos had higher allergen loads than regular shampoos. Fragrance\u2010free\/preservative\u2010free claims conflicted with labels in 21.2%. Fragrance and preservative loads were weakly correlated (Spearman's rho\u2009=\u20090.260,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fragrance and preservative allergens are common in cosmetic and cleaning products in Turkey. More frequent MI and MCI in domestic products suggests limited substitution and possible regulatory gaps; anti\u2010dandruff shampoos warrant caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70207","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T01:35:04Z","timestamp":1782092104000},"page":"396-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fragrance and Preservative Contact Allergens in Cosmetic and Household Cleaning Products in Turkey: Variation by Target Population, Product Type and Manufacturing Origin"],"prefix":"10.1111","volume":"95","author":[{"given":"\u00d6mer","family":"Mang\u0131r","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-9509","authenticated-orcid":false,"given":"Esen","family":"\u00d6zkaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01828.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01647.x"},{"key":"e_1_2_10_4_1","unstructured":"\u201cRegulation (EC) No 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on Cosmetic Products (Recast) (Text With EEA Relevance) \u201daccessed March 10 2026 https:\/\/www.legislation.gov.uk\/eur\/2009\/1223\/contents."},{"key":"e_1_2_10_5_1","unstructured":"\u201cRegulation (EC) No 648\/2004 of the European Parliament and of the Council of 31 March 2004 on Detergents (Text With EEA Relevance) \u201daccessed April 21 2026 https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/?uri=CELEX:32004R0648."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01962.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX01604E"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"239","article-title":"Is It Really Fragrance\u2010Free?","volume":"8","author":"Scheinman P. L.","year":"1997","journal-title":"American Journal of Contact Dermatitis"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14513"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70096"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12446"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70099"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14089"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14397"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02363.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119676881.ch16"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12217"},{"key":"e_1_2_10_18_1","unstructured":"European Commission \u201cCommission Regulation (EU) 2017\/1224\u2010Council on Cosmetic Products. Opinion on Methylisothiazolinone (EC No 1223\/2009) Adopted on 6 July 2017 \u201d2017 accessed March 10 2026 https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/PDF\/?uri=CELEX:32017R1224&from=EN."},{"issue":"5","key":"e_1_2_10_19_1","first-page":"30","article-title":"Commission Regulation (EU) 2019\/831 of May 22, 2019. Amending Annexes II, III and V to Regulation (EC) no 1223\/2009 of the European Parliament and of the Council on Cosmetic Products","volume":"23","year":"2019","journal-title":"Official Journal of the European Union"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14831"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70057"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000067"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08162.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx049831z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12545"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70102"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70033"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14493"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000348"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15875"},{"key":"e_1_2_10_31_1","unstructured":"Turkish Medicines and Medical Devices Agency\u2014Regulatory and Supervisor Authority \u201cRegulation for the Use of Preservatives in Cosmetic Products \u201daccessed March 10 2026 https:\/\/www.resmigazete.gov.tr\/eskiler\/2022\/11\/20221114\u20101.htm."},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70085"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14523"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14641"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14181"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13151"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14818"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.5991"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70104"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14803"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/132564"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2AY26145F"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01945.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.066"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1515\/med-2015-0047"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207324666210712094148"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70207","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:00:36Z","timestamp":1788858036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,21]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/cod.70207"],"URL":"https:\/\/doi.org\/10.1111\/cod.70207","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,21]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}