{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:44:49Z","timestamp":1792122289507,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Propylene glycol (PG) is widely used in cosmetic and pharmaceutical products, yet data on the prevalence of contact allergy to PG and related glycols, and their potential cross\u2010reactivity, remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence of glycol contact allergy, describe clinical characteristics and assess potential cross\u2010reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 1979 patients patch tested at Antwerp University Hospital between January 2021 and December 2024 who were tested with at least one glycol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010five patients (2.79%) were allergic to PG. Detection rates for PG increased with concentration: 5% petrolatum (1.06%), 10% aqueous (0%), 20% aqueous (0.66%), 30% aqueous (2.19%) and 100% (7.82%, selectively tested). Pentylene glycol allergy was found in 6.74% (6\/89) and caprylyl glycol in 0.77% (5% petrolatum) and 0.12% (1% petrolatum). Concomitant reactions to PG occurred in 4\/6 pentylene glycol\u2013allergic and 2\/9 caprylyl glycol\u2013allergic patients. PG\u2010allergic patients were predominantly female (63.6%), with dermatitis mainly affecting the face and hands. Cosmetics (67.3%) were the most common exposure source, followed by topical pharmaceuticals (41.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thirty percent aqueous PG appears more suitable for screening than lower concentrations, and 100% PG may improve detection in selected cases. Cross\u2010reactivity seems limited and is most evident among structurally similar short\u2010chain glycols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70211","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:40:12Z","timestamp":1782880812000},"page":"450-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contact Allergy and Allergic Contact Dermatitis From Propylene Glycol and Related Glycols: Cosmetic Skin Sensitisers After All?"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-2725","authenticated-orcid":false,"given":"Silada","family":"Kanokrungsee","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA\u2010MED Centre of Excellence, University of Antwerp  Antwerp Belgium"},{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-8010","authenticated-orcid":false,"given":"Ella","family":"Dendooven","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA\u2010MED Centre of Excellence, University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2887","authenticated-orcid":false,"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and Research Group Immunology, INFLA\u2010MED Centre of Excellence, University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2023.105341"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000307"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000315"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000393"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.08039"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14224"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13454"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13628"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01201.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2009.00618.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0143"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14469"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.05.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01232.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70019"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14325"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.29017.jdk"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14239"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13332"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581812461381"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1975.tb05336.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1994.tb01995.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000225"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13299"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581812460409"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569520802636082"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000798"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063356"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00693.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01155.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13189"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:06:55Z","timestamp":1792120015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/cod.70211"],"URL":"https:\/\/doi.org\/10.1111\/cod.70211","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2026-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}