{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:59:31Z","timestamp":1785495571027,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Henna has traditionally been considered safe as a natural dye for hair, skin and nails. However, recent reports of dermatitis are increasing. While often linked to para\u2010phenyldiamine (PPD) additives, allergic reactions to pure henna are also emerging. This review aims to provide a focused clinical overview of allergic contact dermatitis (ACD) caused specifically by pure henna. We performed a systematic review of studies reporting on cases of ACD to pure henna. We searched PubMed, SCOPUS and Web of Science without time or language limits. Eligible studies required patch test\u2010confirmed ACD to pure henna, excluding black henna, additives and reviews. Two reviewers independently screened titles, abstracts and full texts. Data on study details, patient characteristics, clinical features, patch testing techniques and treatments were extracted. Of 731 records, 13 met inclusion criteria for ACD to pure henna. Most cases involved women, though children were also affected. Reactions ranged from localised dermatitis to immediate hypersensitivity. Delayed forms were most common, occasionally bullous or pigmented. Patch testing remains the gold standard for delayed reactions, while prick testing aids in immediate hypersensitivity. Management mainly relies on avoidance. Corticosteroids, antihistamines and antibiotics were used in severe cases. Clinicians should remain aware of this uncommon but possible allergy.<\/jats:p>","DOI":"10.1111\/cod.70227","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:19:13Z","timestamp":1785493153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allergic Contact Dermatitis to Pure Henna: A Systematic Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3258-310X","authenticated-orcid":false,"given":"Mounira","family":"Ben Yahia","sequence":"first","affiliation":[{"name":"Dermatology Department Fattouma Bourguiba University Hospital  Monastir Tunisia"},{"name":"Research Laboratory LR 20SP03 University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-3344","authenticated-orcid":false,"given":"Mouna","family":"Korbi","sequence":"additional","affiliation":[{"name":"Dermatology Department Fattouma Bourguiba University Hospital  Monastir Tunisia"},{"name":"Research Laboratory LR 20SP03 University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6684-5167","authenticated-orcid":false,"given":"Hichem","family":"Belhadjali","sequence":"additional","affiliation":[{"name":"Dermatology Department Fattouma Bourguiba University Hospital  Monastir Tunisia"},{"name":"Research Laboratory LR 20SP03 University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-5730","authenticated-orcid":false,"given":"Nesrine Ben","family":"Salah","sequence":"additional","affiliation":[{"name":"Dermatology Department Fattouma Bourguiba University Hospital  Monastir Tunisia"},{"name":"Research Laboratory LR 20SP03 University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8222-0776","authenticated-orcid":false,"given":"Monia","family":"Youssef","sequence":"additional","affiliation":[{"name":"Dermatology Department Fattouma Bourguiba University Hospital  Monastir Tunisia"},{"name":"Research Laboratory LR 20SP03 University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameleddine","family":"Zili","sequence":"additional","affiliation":[{"name":"Dermatology Department Fattouma Bourguiba University Hospital  Monastir Tunisia"},{"name":"Research Laboratory LR 20SP03 University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jep.2014.05.042","article-title":"Lawsonia inermis L. (Henna): Ethnobotanical, Phytochemical and Pharmacological Aspects","volume":"155","author":"Badoni Semwal R.","year":"2014","journal-title":"Journal of Ethnopharmacology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cod.12074","article-title":"Side\u2010Effects of Henna and Semi\u2010Permanent \u2018Black Henna\u2019 Tattoos: A Full Review","volume":"69","author":"Groot A. C.","year":"2013","journal-title":"Contact Dermatitis"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-0536.1980.tb04936.x","article-title":"Contact Dermatitis to Henna (Lawsonia)","volume":"6","author":"Pasricha J. S.","year":"1980","journal-title":"Contact Dermatitis"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-0536.1986.tb01375.x","article-title":"Contact Sensitivity to Henna","volume":"15","author":"Gupta B. N.","year":"1986","journal-title":"Contact Dermatitis"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0536.1988.tb05495.x","article-title":"Allergic Contact Dermatitis From Henna","volume":"18","author":"Nigam P. K.","year":"1988","journal-title":"Contact Dermatitis"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1600-0536.1997.tb00196.x","article-title":"Ectopic Contact Dermatitis From Henna","volume":"37","author":"Etienne A.","year":"1997","journal-title":"Contact Dermatitis"},{"key":"e_1_2_11_8_1","first-page":"298","article-title":"Contact Allergy to Henna","volume":"114","author":"Garc\u00eda Ortiz J. C.","year":"1997","journal-title":"International Archives of Allergy and Immunology"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1046\/j.1365-2133.1999.03086.x","article-title":"Cutaneous Reactions to Henna and Associated Additives","volume":"141","author":"Lestringant G. G.","year":"1999","journal-title":"British Journal of Dermatology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1016\/j.jemermed.2020.06.011","article-title":"Allergic Contact Dermatitis to a Henna Tattoo","volume":"59","author":"Perez V. A.","year":"2020","journal-title":"Journal of Emergency Medicine"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0335-7457(03)00356-3","article-title":"Allergie imm\u00e9diate au henn\u00e9 pur [article in French]","volume":"44","author":"Ben M'Rad S.","year":"2004","journal-title":"Revue Fran\u00e7aise d'Allergologie et d'Immunologie Clinique"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0536.2007.01238.x","article-title":"Contact Dermatitis to Henna Used as a Hair Dye","volume":"58","author":"Belhadjali H.","year":"2008","journal-title":"Contact Dermatitis"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5070\/D378S2J8QW","article-title":"Allergic Contact Dermatitis to Pure Henna","volume":"15","author":"Polat M.","year":"2009","journal-title":"Dermatology Online Journal"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1525-1470.2010.01201.x","article-title":"Bullous Allergic Contact Dermatitis to Pure Henna in a 3\u2010Year\u2010Old Girl","volume":"28","author":"Belhadjali H.","year":"2011","journal-title":"Pediatric Dermatology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.5021\/ad.2018.30.6.735","article-title":"Two Cases of Pigmented Contact Dermatitis Caused by Pure Henna Hair Dyes","volume":"30","author":"Shin J. W.","year":"2018","journal-title":"Annals of Dermatology"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/derm.2024.0334","article-title":"From Chronic Pruritus to Allergic Contact Dermatitis to Henna","volume":"36","author":"Krima H.","year":"2025","journal-title":"Dermatitis"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:19:16Z","timestamp":1785493156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":15,"alternative-id":["10.1111\/cod.70227"],"URL":"https:\/\/doi.org\/10.1111\/cod.70227","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"2025-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cod.70227"}}