{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:05:03Z","timestamp":1789981503212,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Over\u2010ear headphones are a growing source of allergic contact dermatitis (ACD). Identifying well\u2010known and new culprit sensitizers in such products is challenging because of a lack of labelling and limited cooperation from manufacturers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report potential skin sensitizers in occupationally\u2010used headphones from patients attending an occupational allergy clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The over\u2010ear headphones from two octylisothiazolinone (OIT)\u2010allergic patients with ear ACD were chemically analysed using ultra performance liquid chromatography\u2013tandem mass spectrometry (UPLC\u2013MS\/MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      UPLC\u2013MS\/MS confirmed the presence of OIT, but also other biocides (1,2\u2010benzisothiazolin\u20103\u2010one, cetylpyridinium chloride), rubber accelerators (zinc dibenzyldithiocarbamate, 1,3 diphenyl guanidine, 1,3 di\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010tolyguanidine, tetramethylthiuram disulfide, tetraethylthiuram disulfide), acrylates (isobornyl acrylate [IBOA]), plasticizers (triphenyl phosphate [TPP], tricresyl phosphate), oxidizers (benzoylperoxide) and organic solvent (dimethylformamide [DMF]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over\u2010ear headphones may contain reproductive toxicant such as DMF, as well as several sensitizers, including TPP, OIT and IBOA. Under the EU REACH Regulation, the use of DMF is restricted, TPP is listed as a Substance of Very High Concern, whereas OIT and IBOA are not subject to specific restriction. Across both occupational and non\u2010occupational settings, the use of over\u2010ear headphones may cause contact dermatitis due to exposure to various chemical substances. Our findings may serve to explain these and future cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70246","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:41:17Z","timestamp":1789033277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Occupational Allergic Contact Dermatitis From Over\u2010Ear Headphones: Chemical Analysis Reveals Octylisothiazolinone and Other Potential Skin Sensitizers"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8608-1007","authenticated-orcid":false,"given":"Go\u00ebl","family":"Fenech","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Diseases Hotel\u2010Dieu Hospital, APHP. Centre \u2013 Universit\u00e9 Paris Cit\u00e9, AP\u2010HP  Paris France"},{"name":"Private Practice  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1567-7300","authenticated-orcid":false,"given":"Eddy","family":"Langlois","sequence":"additional","affiliation":[{"name":"Polluants Metrology Department Institut National de Recherche et S\u00e9curit\u00e9  Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Polluants Metrology Department Institut National de Recherche et S\u00e9curit\u00e9  Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7331-3670","authenticated-orcid":false,"given":"Catherine","family":"Champmartin","sequence":"additional","affiliation":[{"name":"Polluants Metrology Department Institut National de Recherche et S\u00e9curit\u00e9  Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Bensefa\u2010Colas","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Diseases Hotel\u2010Dieu Hospital, APHP. Centre \u2013 Universit\u00e9 Paris Cit\u00e9, AP\u2010HP  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, CRESS\u2010INSERM UMR\u20101153, HERA Team  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010No\u00eblle","family":"Crepy","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Diseases Hotel\u2010Dieu Hospital, APHP. Centre \u2013 Universit\u00e9 Paris Cit\u00e9, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14528"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14733"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70028"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70195"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15954"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14522"},{"issue":"3","key":"e_1_2_11_8_1","first-page":"164","article-title":"Occupational Contact Dermatitis From Headphones Containing Diethylhexyl Phthalate","volume":"42","author":"Walker S. L.","year":"2000","journal-title":"Contact Dermatitis"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14806"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14715"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14523"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70026"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70087"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1998.tb05808.x"},{"key":"e_1_2_11_15_1","volume-title":"Wearing Your AirPods, EarPods, or Beats Devices","year":"2025"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14255"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70149"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2011.01950.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1323"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1992.tb00241.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1986.tb01367.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12213"},{"key":"e_1_2_11_23_1","unstructured":"\u201cCandidate List\u2014ECHA CHEM \u201daccessed July 6 2026 https:\/\/chem.echa.europa.eu\/obligation\u2010lists\/candidateList?pageIndex=1&pageSize=100."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2009.01603.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14166"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-74165-7"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1987.tb01440.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229\u20105178.190501"},{"key":"e_1_2_11_29_1","unstructured":"\u201cCommission Regulation (EU) 2021\/2030 of 19 November 2021 Amending Annex XVII to Regulation (EC) No 1907\/2006 of the European Parliament and of the Council Concerning the Registration Evaluation Authorisation and Restriction of Chemicals (REACH) as Regards N N\u2010Dimethylformamide \u201daccessed August 2 2026 https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/PDF\/?uri=CELEX:32021R2030."}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70246","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:33:56Z","timestamp":1789979636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":28,"alternative-id":["10.1111\/cod.70246"],"URL":"https:\/\/doi.org\/10.1111\/cod.70246","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2026-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cod.70246"}}