{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:03:43Z","timestamp":1790075023840,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paraphenylenediamine (PPD) is a potent allergen, frequently responsible for allergic contact dermatitis (ACD) from hair dyes and temporary \u2018black henna\u2019 tattoos. Misleading \u2018PPD\u2010free\u2019 labelling may expose sensitised individuals to structurally related aromatic amines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterise clinical features, cross\u2010reactivity and outcomes of patients diagnosed with PPD ACD following diagnosis of PPD allergy, and to evaluate the accuracy and safety of \u2018PPD\u2010free\u2019 products marketed in the United Kingdom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study of PPD positivity between 2018 and 2025 at a university hospital was conducted. Demographic, clinical and exposure data were extracted from records, and outcomes post\u2010diagnosis were surveyed by telephone. Ingredient lists of permanent \u2018PPD\u2010free\u2019 hair dyes\/tints identified through a structured online search were reviewed for cross\u2010reactive amines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1306 patients tested for PPD over 7\u2009years, 56 (4.3%) had a positive reaction. The mean age of affected patients was 49\u2009years; 82% were female, and hair dye was the most frequently reported source of exposure (77%). Eight (14%) had occupational exposure. Among 37 tested to para\u2010toluenediamine (PTD), 10 (27%) were positive. Among 31 followed up, 24 (77%) reported remission after avoidance. Only 1 of 10 permanent \u2018PPD\u2010free\u2019 hair dyes\/tints examined was found to be free of any potentially cross\u2010reactive amines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PPD remains a prevalent allergen causing chronic and occupational ACD. \u2018PPD\u2010free\u2019 products frequently contain cross\u2010reactive amines, highlighting the need for improved labelling and careful counselling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70250","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:05:39Z","timestamp":1790071539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paraphenylenediamine Contact Allergy and Post\u2010Diagnostic Outcomes: A Single\u2010Centre Study From the United Kingdom"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-1387","authenticated-orcid":false,"given":"Zara","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-9128","authenticated-orcid":false,"given":"Livia Francine","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6696-0467","authenticated-orcid":false,"given":"Michelle","family":"Oakford","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6936-3895","authenticated-orcid":false,"given":"Ying","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/cod.12583","article-title":"ESSCA Results With the Baseline Series, 2002\u20132012: p\u2010Phenylenediamine","volume":"75","author":"Schuttelaar M. 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