{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:54:58Z","timestamp":1790819698356,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic contact dermatitis from nail cosmetics is common. Most patients are allergic to HEMA. Increasingly, products are labelled \u2018HEMA\u2010free\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To use ingredient lists to assess changes in the use of HEMA, Di\u2010HEMA trimethylhexyl dicarbamate (Di\u2010HEMA TMHDC), and other (meth)acrylates in nail cosmetics, and to investigate whether HEMA and Di\u2010HEMA TMHDC occur in products not marketed for professional use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We searched online for 394 products from 2023 and compared the 2023 and 2026 ingredient lists of products with the same brand and commercial name.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 127 matched products, HEMA decreased from 65.4% to 16.5% (\u221275%) and Di\u2010HEMA TMHDC from 27.6% to 7.1% (\u221274%). Trimethylolpropane triacrylate and urethane acrylate decreased by 63% and 54%, respectively. Benzyl methacrylate, urethane methacrylate, and trimethylolpropane trimethacrylate increased by 100%\u2013225%. Four of 24 products containing HEMA and\/or Di\u2010HEMA TMHDC (16.7%; 3.1% overall) were apparently marketed directly to consumers without an identifiable online professional\u2010use restriction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among matched nail cosmetics, ingredient lists indicated that the use of HEMA and Di\u2010HEMA TMHDC decreased by approximately 75% over 3\u2009years, while the use of several other (meth)acrylates changed substantially. Few products containing HEMA and\/or Di\u2010HEMA TMHDC appeared to be marketed directly to consumers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70255","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:56:57Z","timestamp":1790816217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond\n                    <scp>HEMA<\/scp>\n                    : Shifts in the (Meth)acrylate Composition of Matched Nail Cosmetics Between 2023 and 2026"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-4131","authenticated-orcid":false,"given":"Norbertus A.","family":"Ipenburg","sequence":"first","affiliation":[{"name":"Dermato\u2010Allergology and Occupational Dermatology Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-7292","authenticated-orcid":false,"given":"Anton C.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Dermato\u2010Allergology and Occupational Dermatology Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-0684","authenticated-orcid":false,"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Dermato\u2010Allergology and Occupational Dermatology Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14441"},{"key":"e_1_2_10_3_1","first-page":"31","article-title":"Commission Regulation (EU) 2020\/1682 of November 12, 2020 Amending Annex III to Regulation (EC) No 1223\/2009 of the European Parliament and of the Council on Cosmetic Products","volume":"379","author":"Commission Regulation (EU)","year":"2020","journal-title":"Official Journal of the European Union"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14405"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14683"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14430"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14485"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14745"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14800"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:56:58Z","timestamp":1790816218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":8,"alternative-id":["10.1111\/cod.70255"],"URL":"https:\/\/doi.org\/10.1111\/cod.70255","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cod.70255"}}