{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:53:02Z","timestamp":1791273182965,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006286","name":"Kongelig Hofbuntmager Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002784","name":"Canada Excellence Research Chairs, Government of Canada","doi-asserted-by":"publisher","award":["CRC\u20102024\u201000200"],"award-info":[{"award-number":["CRC\u20102024\u201000200"]}],"id":[{"id":"10.13039\/501100002784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gold contact allergy is common, but its clinical relevance is often uncertain. A previous study of low\u2010cost gold\u2010plated earrings found frequent nickel release and detectable gold release under cysteine\u2010modified artificial sweat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To assess surface composition and release of gold, nickel and copper from jeweller\u2010purchased earrings marketed as\n                      <jats:styled-content style=\"fixed-case\">10K<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">14K<\/jats:styled-content>\n                      gold.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five pairs of earrings were examined by scanning electron microscopy (\n                      <jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\n                      ) with energy\u2010dispersive spectroscopy (\n                      <jats:styled-content style=\"fixed-case\">EDS<\/jats:styled-content>\n                      ). Release testing used cysteine\u2010modified artificial sweat at\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      8.0\u2009\u00b1\u20090.2 and 30\u00b0C for 168\u2009h. Metals were quantified by inductively coupled plasma mass spectrometry (\n                      <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Surfaces consisted mainly of gold, copper, silver and zinc.\n                      <jats:styled-content style=\"fixed-case\">EDS<\/jats:styled-content>\n                      \u2010detected gold ranged from 40 to 63\u2009wt%, and nickel from 0.085 to 0.20\u2009wt%. Nickel release was &lt;\u2009\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      in all pairs. Gold release was detected from all pairs (median 0.057\u2009\u03bcg\/cm\n                      <jats:sup>2<\/jats:sup>\n                      \/week, range: 0.016\u20130.15). Copper release exceeded gold release in all samples (median: 0.53\u2009\u03bcg\/cm\n                      <jats:sup>2<\/jats:sup>\n                      \/week, range: 0.36\u20132.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Jeweller\u2010purchased\n                      <jats:styled-content style=\"fixed-case\">10K<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">14K<\/jats:styled-content>\n                      gold earrings released measurable gold but not detectable nickel under cysteine\u2010modified artificial sweat conditions. Gold release provides a plausible exposure pathway but does not establish sensitization or elicitation risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70257","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:17:37Z","timestamp":1790817457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gold and Nickel Release From Jeweller\u2010Purchased\n                    <scp>10K<\/scp>\n                    and\n                    <scp>14K<\/scp>\n                    Gold Earrings in Cysteine\u2010Modified Artificial Sweat"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-5735","authenticated-orcid":false,"given":"Mikkel Bak","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, National Allergy Research Centre Herlev and Gentofte Hospital  Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-9381","authenticated-orcid":false,"given":"Saman","family":"Nikpour","sequence":"additional","affiliation":[{"name":"Department of Chemistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-6443","authenticated-orcid":false,"given":"Ren\u00e9 D.","family":"P\u00fctz","sequence":"additional","affiliation":[{"name":"Department of Chemistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3216-7149","authenticated-orcid":false,"given":"Bruce","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2145-3650","authenticated-orcid":false,"given":"Yolanda S.","family":"Hedberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry Western University  London Ontario Canada"},{"name":"Surface Science Western Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, National Allergy Research Centre Herlev and Gentofte Hospital  Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14707"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000477"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1998.tb05942.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.09.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101541"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1116\/6.0000910"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70187"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12775"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/J.1600\u20100536.2000.043006344.X"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1595\/205651321X16189971801978"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020\u20101693(00)85035\u20105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14837"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1149\/1945\u20107111\/acb61c"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.04.017"}],"container-title":["Contact 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