{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:47:04Z","timestamp":1791996424594,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gold sensitization is common, but its clinical and immunologic significance remains unclear. European data from consecutively patch tested patients are scarce. Animal models suggest that gold can induce systemic autoimmunity, but studies in humans are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize gold sodium thiosulphate (GST) patch test positive patients, including co\u2010sensitization patterns to other metals and determine whether gold sensitization is linked to autoimmune diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective register\u2010based study including 3436 dermatitis patients consecutively patch tested between 2015 and 2024 at Odense University Hospital, Denmark. Patch test results were linked to diagnostic data from the Danish National Patient Registry. Autoimmune diseases were grouped into six categories analysed using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Gold sensitization was found in 18.7% of tested patients and was more common in women (OR 2.38, 95% CI 1.96\u20132.94) and at an age above 40\u2009years (OR 1.32, 95% CI 1.09\u20131.60). Concomitant sensitization to Ni, Cr and Co increased with higher gold reactivity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). No association was observed between gold sensitization and autoimmune diseases, overall (OR 1.00, 95% CI 0.82\u20131.22).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A positive patch test to GST was associated with other metal allergies but not with any autoimmune diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70264","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:38:11Z","timestamp":1791383891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gold Contact Sensitization, Clinical Characteristics and Associations With Autoimmune Disease: A Retrospective Cohort Study With Registry Linkage"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-5735","authenticated-orcid":false,"given":"Mikkel Bak","family":"Jensen","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Gentofte Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin Glindvad","family":"Ahstr\u00f6m","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Gentofte Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital\u2014Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8109-8639","authenticated-orcid":false,"given":"Jannat","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital\u2014Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-3280","authenticated-orcid":false,"given":"Nikolai","family":"Loft","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital\u2014Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-0829","authenticated-orcid":false,"given":"Charlotte G.","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital  Gentofte Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14707"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1999.tb06079.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.70187"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502753600876"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.03.038"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.07015"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555577370373"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v105.42463"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12395"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102531"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78088"},{"issue":"3","key":"e_1_2_10_14_1","first-page":"1","article-title":"Burden of Autoimmune Disorders; 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