{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:39:23Z","timestamp":1792543163959,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018403","name":"Ministerie van Sociale Zaken en Werkgelegenheid","doi-asserted-by":"publisher","award":["2025\u20100000155817"],"award-info":[{"award-number":["2025\u20100000155817"]}],"id":[{"id":"10.13039\/100018403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>Occupational hand dermatitis (HD) comprises irritant and allergic contact dermatitis (ICD and ACD), which share clinical features, often overlap, and may coexist with atopic dermatitis (AD), complicating diagnosis. The objective of this study is to explore whether stratum corneum (SC) biomarkers discriminate ICD from ACD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>We recruited 126 patients from the Occupational Dermato\u2010allergology Clinics of the Amsterdam UMC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SC samples were collected from lesional HD skin and patch test reactions to nickel, chromium, methylisothiazolinone, sodium lauryl sulfate (irritant), and control sites. Thirty\u2010three biomarkers were analyzed. Random forest and penalized regression models were trained on the patch test dataset and validated in HD; an additional model was trained and validated in HD. Exploratory analyses evaluated discrimination among individual allergens and between AD, ICD and ACD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patch test model showed good discrimination between ICD and ACD (mean AUC 0.85, 95% CI 0.82\u20130.87), driven primarily by skin barrier\u2013related biomarkers. In HD, performance declined (mean AUC 0.51, 95% CI 0.26\u20130.76); sensitivity for ACD was 88%. Model trained and validated within HD achieved mean AUC of 0.60 (95% CI 0.57\u20130.64). Discrimination between individual allergens yielded mean AUC of 0.75 (95% CI 0.72\u20130.77).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SC biomarkers discriminated ICD from ACD good in acute patch test, but showed limited discrimination in HD, reflecting differences between acute and chronic inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70268","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:13:27Z","timestamp":1792541607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stratum Corneum Biomarkers for Differentiating Irritant and Allergic Contact Dermatitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7595-7608","authenticated-orcid":false,"given":"F. L.","family":"de Boer","sequence":"first","affiliation":[{"name":"Public and Occupational Health Department Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1063-4547","authenticated-orcid":false,"given":"S.","family":"Kezic","sequence":"additional","affiliation":[{"name":"Public and Occupational Health Department Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-4069","authenticated-orcid":false,"given":"Ivone","family":"Jakasa","sequence":"additional","affiliation":[{"name":"Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nique M.","family":"Grob","sequence":"additional","affiliation":[{"name":"Public and Occupational Health Department Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2007-5161","authenticated-orcid":false,"given":"Nariman K. A.","family":"Metwally","sequence":"additional","affiliation":[{"name":"Public and Occupational Health Department Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u03cbrgen","family":"Claesen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam UMC, VU Amsterdam  Amsterdam the Netherlands"},{"name":"Data Science Institute Hasselt University  Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Ghauharali\u2010van","family":"der Vlugt","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Location University of Amsterdam, Department of Laboratory Medicine and Pediatrics, Laboratory Genetic Metabolic Diseases Emma Children's Hospital  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Inborn Errors of Metabolism  Amsterdam the Netherlands"},{"name":"Core Facility Metabolomics Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke S.","family":"Beers\u2010Stet","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Location University of Amsterdam, Department of Laboratory Medicine and Pediatrics, Laboratory Genetic Metabolic Diseases Emma Children's Hospital  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Inborn Errors of Metabolism  Amsterdam the Netherlands"},{"name":"Core Facility Metabolomics Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-9358","authenticated-orcid":false,"given":"Wouter","family":"Ouwerkerk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute  Amsterdam the Netherlands"},{"name":"National Heart Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-0684","authenticated-orcid":false,"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Dermato\u2010Allergology and Occupational Dermatology Amsterdam University Medical Centers  Noord\u2010Holland the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-2020","authenticated-orcid":false,"given":"Henk F.","family":"van der Molen","sequence":"additional","affiliation":[{"name":"Public and Occupational Health Department Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8713-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2021.04.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14167"},{"issue":"3","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.det.2020.02.002","article-title":"Occupational Contact Dermatitis: Common Occupational Allergens","volume":"38","author":"Chu C.","year":"2020","journal-title":"Dermatologic Clinics"},{"issue":"2","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1710-1492-4-2-59","article-title":"Occupational Contact Dermatitis","volume":"4","author":"Sasseville D.","year":"2008","journal-title":"Allergy, Asthma & Clinical Immunology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.shaw.2014.08.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2019.12.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009192117"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8685-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14989"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.12.024"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700412"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.03.1160"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.01.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.2983"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13746"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12770"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14391"},{"issue":"1","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"40014","DOI":"10.1038\/s41598-025-23579-7","article-title":"Comparison of Three Multiplex Immunoassays for Biomarker Analysis in Stratum Corneum Tape Strips","volume":"15","author":"Metwally N. K. A.","year":"2025","journal-title":"Scientific Reports"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20979"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2011.00771.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102102699"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-91"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01911.x"},{"issue":"6","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/cod.70070","article-title":"Skin Barrier Biomarkers in Patch\u2010Induced and Clinical Allergic and Irritant Contact Dermatitis","volume":"94","author":"Kezic S.","year":"2026","journal-title":"Contact Dermatitis"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611665114"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01662"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14015"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.11.066"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15538"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.01.026"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.70268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.70268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:13:29Z","timestamp":1792541609000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.70268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":34,"alternative-id":["10.1111\/cod.70268"],"URL":"https:\/\/doi.org\/10.1111\/cod.70268","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"2026-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cod.70268"}}