{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:42:01Z","timestamp":1792370521063,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with negative patch test (NPT) results do not receive allergy avoidance counselling, and their experiences are important to understand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinical presentation and outcomes associated with NPT results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional study analysing data from an IRB\u2010approved REDCap registry. A systematic review was performed searching Ovid MEDLINE, Embase and Cochrane Library Databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      161\/1001 patients (769 female, 230 male) 16.1%, had NPTs. Mean age was 52.2\u2009years (standard deviation 20.6). Median age, female predominance, race\/ethnicity, duration of rash and number of patches placed was not significantly different between negative and positive patch test results. More NPT patients had leg involvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and prior biopsy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). 29.9% had a non\u2010dermatitis diagnosis. The investigator and patient assessments were significantly improved post\u2010patch testing. In a systematic review of 34 studies, 77261 patients, the NPT rate ranged between 16.7% and 83.1% and number of patches placed from 20 to 102. The most common areas of dermatitis were the hands.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our cohort and systematic review, a minority of patients have NPTs, with no major demographic differences. NPT patients have had prior biopsies, suggesting an unusual presentation. They were also commonly diagnosed with other forms of dermatitis, although 30% had a non\u2010dermatitis diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.70270","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:25:26Z","timestamp":1792369526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics and Outcomes of Patients With Negative Patch Test Results and Systematic Literature Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4283-7783","authenticated-orcid":false,"given":"Conan H.","family":"Lee","sequence":"first","affiliation":[{"name":"School of Medicine University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren W.","family":"Hastings","sequence":"additional","affiliation":[{"name":"Des Moines University College of Osteopathic Medicine  West Des Moines Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9623-2251","authenticated-orcid":false,"given":"Nicholas T.","family":"Le","sequence":"additional","affiliation":[{"name":"School of Medicine University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Bryan","family":"De Guzman","sequence":"additional","affiliation":[{"name":"School of Medicine University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6976-4445","authenticated-orcid":false,"given":"Jasmin K.","family":"Johl","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5350-7815","authenticated-orcid":false,"given":"Bruce","family":"Abbott","sequence":"additional","affiliation":[{"name":"Blaisdell Medical Library University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy A.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.clindermatol.2021.03.005","article-title":"Patch Testing: Uses, Systems, Risks\/Benefits, and Its Role in Managing the Patient With Contact Dermatitis","volume":"39","author":"Garg V.","year":"2021","journal-title":"Clinics in Dermatology"},{"issue":"6","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/ijd.17021","article-title":"Exploring the Relationship Between Allergic Contact Dermatitis and Atopic Dermatitis in Children: Insights From a Retrospective Patch Testing Analysis","volume":"63","author":"Andre N.","year":"2024","journal-title":"International Journal of Dermatology"},{"issue":"7","key":"e_1_2_11_4_1","first-page":"2853","article-title":"Prevalence and Trend of Allergen Sensitization in Adults and Children With Atopic Dermatitis Referred for Patch Testing, North American Contact Dermatitis Group Data, 2001\u20102016","volume":"9","author":"Silverberg J. I.","year":"2021","journal-title":"Journal of Allergy and Clinical Immunology: In Practice"},{"issue":"3","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/cod.13535","article-title":"Assessment of the Quality of Life (QoL) of Patients With Dermatitis and the Impact of Patch Testing on QoL: A Study of 519 Patients Diagnosed With Dermatitis","volume":"83","author":"Boonchai W.","year":"2020","journal-title":"Contact Dermatitis"},{"issue":"5","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/DER.0000000000000222","article-title":"Proposed ICDRG Classification of the Clinical Presentation of Contact Allergy","volume":"27","author":"Pongpairoj K.","year":"2016","journal-title":"Dermatitis"},{"issue":"5","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1089\/derm.2024.0474","article-title":"North American Contact Dermatitis Group Patch Test Results: 2021\u20102022","volume":"36","author":"Houle M. 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