{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:03:22Z","timestamp":1765667002644},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> Lifetime risk of a metachronous colorectal cancer (mCRC) is 0.6\u20133% following sporadic colorectal cancer (CRC) and 15\u201326% in Lynch syndrome. The lifetime incidence of CRC in individuals with moderate familial risk is 8\u201317%. Risk of mCRC is unknown.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> A retrospective longitudinal study of the Regional Familial CRC Registry was performed. Patients who had at least one CRC were categorized as follows: moderate risk (<jats:italic>n<\/jats:italic>\u2003=\u2003383), Lynch syndrome (<jats:italic>n<\/jats:italic>\u2003=\u2003528) and average (population) risk (<jats:italic>n<\/jats:italic>\u2003=\u2003409). The Kaplan\u2013Meier estimate (1\u2010KM) and the cumulative incidence function were used to calculate the risk of mCRC. The 1\u2010KM gives the risk for individuals remaining at risk (alive) at a given time point and thus is useful for counselling. The cumulative incidence function gives the risk for the whole population.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The 1\u2010KM and the cumulative incidence function demonstrated that the risk of mCRC was significantly higher in moderate\u2010risk patients compared with average (population)\u2010risk patients (1\u2010KM, <jats:italic>P<\/jats:italic>\u2003=\u20030.008; cumulative incidence function, <jats:italic>P<\/jats:italic>\u2003=\u20030.00097). However, the risk of mCRC was higher in patients with Lynch syndrome than in moderate\u2010risk or average (population)\u2010risk patients. The 1\u2010KM in moderate\u2010risk patients was 2.7%, 6.3% and 23.5% at 5, 10 and 20\u2003years, respectively. In average (population)\u2010risk patients, the 1\u2010KM was 1.3%, 3.1% and 7.0% at 5, 10 and 20\u2003years, and the cumulative incidence function was 0.3%, 0.6% and 2.4% at the same time points, respectively.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> These data indicate that the risk of mCRC is significantly higher in patients with a moderate family history of CRC than in those with an average (population) risk. This justifies proactive lifelong surveillance.<\/jats:p>","DOI":"10.1111\/codi.12005","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T16:07:19Z","timestamp":1346688439000},"page":"309-316","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metachronous colorectal cancer risk in patients with a moderate family history"],"prefix":"10.1111","volume":"15","author":[{"given":"K. 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