{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:13:38Z","timestamp":1788779618090,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> Chronic radiation proctitis is a long\u2010term complication of radiation therapy for pelvic malignancy. The aim of this study was to compare the efficacy and safety of two treatment regimens, sucralfate or placebo, following argon plasma coagulation (APC) for chronic haemorrhagic radiation proctitis.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> A single\u2010centre, randomized, placebo\u2010controlled, double\u2010blind study was performed on patients with haemorrhagic chronic radiation proctitis after irradiation for prostate, uterine, cervical, rectal or vaginal cancer. All patients received APC, and were then randomized to oral sucralfate (6\u2003g twice a day) or placebo treatment for 4\u2003weeks. APC was repeated every 8\u2003weeks if necessary after the first session. Patients were graded clinically and endoscopically according to the Chutkan and Gilinski scales before and at 8 and 16\u2003weeks after initial APC treatment (1.5\u20132\u2003l\/min, 25\u201340\u2003W) and after 52\u2003weeks (clinical only).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Of 122 patients, 117 completed the entire protocol, with 57\/60 in the sucralfate group and 60\/62 in the placebo group. At baseline there were no significant differences between the sucralfate and placebo groups. At 1\u2003year, a significant improvement in the clinical scale in both groups occurred compared with baseline. After 16\u2003weeks, the median overall clinical severity scores fell from 4 to 2 points and the median bleeding score from 2 to 0 in both groups.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> APC is safe and effective for the management of chronic radiation proctitis. Additional sucralfate treatment did not influence the clinical or endoscopic outcome.<\/jats:p>","DOI":"10.1111\/codi.12035","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T02:29:13Z","timestamp":1348540153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Sucralfate or placebo following argon plasma coagulation for chronic radiation proctitis: a randomized double blind trial"],"prefix":"10.1111","volume":"15","author":[{"given":"M. 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