{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:36Z","timestamp":1772160096769,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this review was to assess and evaluate reports of studies on the efficacy of anal bulking agents used in the treatment of faecal incontinence. A systematic review of the literature was carried out to identify studies that have reported on the use of anal bulking agents.<\/jats:p>\n                  <jats:p>A variety of biomaterials have been employed for anal bulking. These include autologous fat, bovine glutaraldehyde cross\u2010linked collagen, carbon\u2010coated zirconium oxide beads, dextranomer microspheres in a gel, hydrogel cross\u2010linked with polyacrylamide, polydimethylsiloxane elastomer in a gel, porcine dermal collagen and synthetic calcium hydroxylapatitie ceramic microspheres. Although the ideal site of injection (submucosal or intramuscular) and the mechanism of action remain the subject of debate, most published studies report a significant improvement in continence in at least 50% of subjects with mild to moderate symptoms with little or no associated morbidity.We concluded that anal bulking agents may be used to alleviate symptoms of faecal seepage and soilage.<\/jats:p>","DOI":"10.1111\/codi.12047","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T09:17:42Z","timestamp":1352366262000},"page":"29-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Anal bulking agents for faecal incontinence"],"prefix":"10.1111","volume":"14","author":[{"given":"N. F. S.","family":"Watson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Sagar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7427.1299"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00298538"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09188-X"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6597"},{"key":"e_1_2_10_6_2","first-page":"CD001757","article-title":"Surgery for faecal incontinence in adults","volume":"8","author":"Brown SR","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_7_2","first-page":"CD007959","article-title":"Perianal injectable bulking agents as treatment for faecal incontinence in adults","volume":"12","author":"Maeda Y","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199579624.003.0022"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0760-3"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5394"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03293.x"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01318.x"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01634.x"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62297-0"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.01828.x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7645"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12047","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:27:20Z","timestamp":1694464040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,8]]},"references-count":15,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/codi.12047"],"URL":"https:\/\/doi.org\/10.1111\/codi.12047","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717964980.793466144","asserted-by":"object"}]},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,8]]},"assertion":[{"value":"2012-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}