{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:27:52Z","timestamp":1790969272481,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Systemic sclerosis (SS<\/jats:styled-content>c) is a generalized connective tissue disease that affects smooth muscle cells. Patients with SS<\/jats:styled-content>c often have faecal incontinence caused by fibrotic degeneration of the internal anal sphincter (IAS<\/jats:styled-content>). The functional lumen imaging probe (FLIP<\/jats:styled-content>) is a novel method that allows the segmental biomechanical properties of the anal canal to be dynamically evaluated. The aim of the present study was to compare the segmental biomechanical properties of the anal canal in incontinent SS<\/jats:styled-content>c patients and healthy controls. We hypothesized that the FLIP<\/jats:styled-content> would reveal weaknesses of the IAS<\/jats:styled-content> in the SS<\/jats:styled-content>c patients.<\/jats:p><\/jats:sec>Method<\/jats:title>We performed FLIP<\/jats:styled-content> distensions, endoanal ultrasonography and standard anal manometry on 14 incontinent SS<\/jats:styled-content>c patients [11 women, median age 60\u00a0years (range 35\u201380)] and 15 healthy volunteers [12 women, median age 54\u00a0years (range 33\u201367)]. The anal canal was divided into three parts for the biomechanical analysis: upper (surrounded by the IAS<\/jats:styled-content> and the puborectalis), middle (IAS<\/jats:styled-content> and external anal sphincter) and lower (external sphincter only).<\/jats:p><\/jats:sec>Results<\/jats:title>The middle anal canal was the segment most resistant to distension in all of the subjects, but it was less resistant in the SS<\/jats:styled-content>c patients than in the controls (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01). Correspondingly, the endoanal ultrasonography showed that the IAS<\/jats:styled-content> of the SS<\/jats:styled-content>c patients was thinner than normal (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05), and the anal resting and squeeze pressures were lower (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). Only minor distensibility differences were found in the upper anal canal. No changes were found in the lower anal canal.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Faecal incontinence in SS<\/jats:styled-content>c patients is associated with poor IAS<\/jats:styled-content> function, causing increased distensibility of the middle anal canal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12063","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T09:38:56Z","timestamp":1350380336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Distensibility of the anal canal in patients with systemic sclerosis: a study with the functional lumen imaging probe"],"prefix":"10.1111","volume":"15","author":[{"given":"L.","family":"Fynne","sequence":"first","affiliation":[{"name":"Neurogastroenterology Unit Department of Hepatology and Gastroenterology V Aarhus 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