{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:07:03Z","timestamp":1788836823169,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aimed to determine whether faecal haemoglobin (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b) concentration can assist in deciding who with lower abdominal symptoms will benefit from endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Faecal <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b concentrations were measured on single samples from 280 patients referred for lower gastrointestinal tract endoscopy from primary care in <jats:styled-content style=\"fixed-case\">NHS T<\/jats:styled-content>ayside who completed a faecal immunochemical test (<jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b and underwent subsequent endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 739 invited patients, <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content> and endoscopy were completed by 280 (median age 63 (18\u201384) years; 59.6% women), with a median time between <jats:styled-content style=\"fixed-case\">FIT<\/jats:styled-content> and endoscopy of 9\u00a0days. Six (2.1%) participants had cancer, 23 (8.2%) had high\u2010risk adenoma (<jats:styled-content style=\"fixed-case\">HRA<\/jats:styled-content>) (more than three adenomas or any &gt;\u00a01\u00a0cm), 31 (11.1%) low\u2010risk adenoma (<jats:styled-content style=\"fixed-case\">LRA<\/jats:styled-content>) and 26 (9.3%) inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) as the most serious diagnosis. Those with cancer had a median faecal <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b of &gt;\u00a01000\u00a0ng\u00a0Hb\/ml buffer. Those with cancer\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">HRA<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> had a median faecal <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b concentration of 75\u00a0ng\u00a0Hb\/ml buffer (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 18\u2013204), which was significantly higher than that of all remaining participants without significant colorectal disease (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Using a cut\u2010off faecal <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b concentration of 50\u00a0ng\u00a0Hb\/ml buffer, negative predictive values of 100.0%, 94.4%, 93.4% and 93.9% were found for cancer, <jats:styled-content style=\"fixed-case\">HRA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LRA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>. Patients with reasons for referral other than rectal bleeding and family history did not have high faecal <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Faecal <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b concentration measurements have considerable potential to contribute to reducing unnecessary endoscopy for the majority of symptomatic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12087","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T14:40:18Z","timestamp":1354286418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Low faecal haemoglobin concentration potentially rules out significant colorectal disease"],"prefix":"10.1111","volume":"15","author":[{"given":"P. J.","family":"McDonald","sequence":"first","affiliation":[{"name":"Scottish Bowel Screening Centre Kings Cross Hospital Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Digby","sequence":"additional","affiliation":[{"name":"Scottish Bowel Screening Centre Kings Cross Hospital Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Innes","sequence":"additional","affiliation":[{"name":"Department of Surgery Ninewells Hospital and Medical School Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Strachan","sequence":"additional","affiliation":[{"name":"Scottish Bowel Screening Centre Kings Cross Hospital Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. A.","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Pathology Ninewells Hospital and Medical School Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J. C.","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Surgery Ninewells Hospital and Medical School Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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