{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:25:52Z","timestamp":1791444352695,"version":"4.3.3"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A systematic review was carried out to analyse continence at 2\u00a0years or more after lateral internal sphincterotomy (<jats:styled-content style=\"fixed-case\">LIS<\/jats:styled-content>) for chronic anal fissure (<jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>PubMed, <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> S<\/jats:styled-content>copus, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mbase, <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>vid, <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>entral <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egister of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ontrolled <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials (<jats:styled-content style=\"fixed-case\">CENTRAL<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>oogle <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cholar were used to search the literature from 1969\u20132012 for studies reporting a follow\u2010up of more than 2\u00a0years after <jats:styled-content style=\"fixed-case\">LIS<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>. The primary outcome parameter analysed was continence. The secondary outcome parameters included success rate, recurrence, incidence of postoperative abscess and fistula formation and patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 324 studies screened, 22 (<jats:italic>n<\/jats:italic>\u00a0=\u00a04512) were included. The mean follow\u2010up period ranged from 24\u2013124\u00a0months. The overall continence disturbance rate was 14% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.09\u20130.2). Weighted analysis showed flatus incontinence in 9% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.04\u20130.16), soilage\/seepage in 6% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.03\u20130.1), accidental defaecation in 0.91% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.003\u20130.02), incontinence to liquid stool in 0.67% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.001\u20130.02) and incontinence to solid stool in 0.83% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.003\u20130.02) of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The long\u2010term risk of continence disturbance after lateral internal sphincterotomy is significant. Randomized controlled trials with a long follow\u2010up are needed to substantiate these findings and to redefine its role in the treatment of chronic anal fissure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12108","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T17:52:46Z","timestamp":1358272366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Long\u2010term continence disturbance after lateral internal sphincterotomy for chronic anal fissure: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"P.","family":"Garg","sequence":"first","affiliation":[{"name":"Fortis Super Specialty Hospital Mohali India"},{"name":"MM Institute of Medical Sciences and Research Mullana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garg","sequence":"additional","affiliation":[{"name":"Indus Super Speciality Hospital Mohali India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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