{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T11:10:09Z","timestamp":1743937809331,"version":"3.40.3"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A barostat can be used to measure rectal sensitivity, compliance and elastance all of which are potentially important physiological parameters in the pathophysiology of faecal incontinence. Current practice recommends a conditioning distension sequence be performed prior to index distensions. We questioned the validity of this by comparing values for rectal compliance during sequential conditioning (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) and index (<jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>) distensions in physiologically normal subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Ten subjects (five men, mean age 55.2\u00a0years) with normal anal canal manometry, anorectal sensitivity and balloon distension thresholds were studied. After determining the minimum distension pressure, subjects underwent sequential isobaric distensions: <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> 4\u00a0mmHg distensions every 45\u00a0s and <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content> 4\u00a0mmHg every 2\u00a0min, both to a maximum of 24\u00a0mmHg or patient tolerance. Compliance values from both sequences were calculated by measuring the maximum slope of pressure\u2013volume curves. A paired <jats:italic>t<\/jats:italic>\u2010test was performed to compare any differences between sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean rectal compliance were 11.4\u00a0ml\/mmHg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 5.8\u00a0ml\/mmHg) and 10.9\u00a0ml\/mmHg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 5.7\u00a0ml\/mmHg) in the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>, respectively, with no statistical difference noted between distensions (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rectal compliance can be measured with a single distension protocol without the need for an initial conditioning distension. Conditioning the rectum adds additional complexity to barostat protocols and is not necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12109","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T17:52:45Z","timestamp":1358272365000},"page":"715-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The utility of conditioning sequences in barostat protocols for the measurement of rectal compliance"],"prefix":"10.1111","volume":"15","author":[{"given":"A.","family":"Bajwa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Nutrition University College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Thiruppathy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition University College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition University College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312233292601"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02055596"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01144.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.687"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018885028501"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.274.3.G584"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02156270"},{"key":"e_1_2_9_9_1","first-page":"G17","article-title":"Variations in muscle tone of the human rectum: recordings with an electromechanical barostat","volume":"260","author":"Bell AM","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1997.273.5.G997"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2005.02.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050086"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.00439.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.047696"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6353-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01050-3"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T10:38:34Z","timestamp":1743935914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/codi.12109"],"URL":"https:\/\/doi.org\/10.1111\/codi.12109","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"type":"print","value":"1462-8910"},{"type":"electronic","value":"1463-1318"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"2012-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}