{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:39:22Z","timestamp":1767915562750,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Twelve to thirty % of colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) patients and relatives with an increased familial risk of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> are referred for preventive measures. New guidelines recommend genetic counselling for high\u2010risk families and surveillance colonoscopy for moderate\u2010risk families. Assessment of familial risk of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> and referral rates for these preventive measures were determined 1\u00a0year after the introduction of new guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Assessment of familial risk of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> and referral for preventive measures were measured in clinical practice among 358 patients with <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> in 18 hospitals using medical records and questionnaires. Additionally, a knowledge survey was performed among 312 clinicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven % of patients with an increased familial risk (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>65\/97) were referred for preventive measures, as were 23% (61\/261) of low\u2010risk patients. The uptake of genetic counselling in high\u2010risk families was 33% (12\/36). The uptake of surveillance colonoscopy in moderate\u2010risk families was 34% (21\/61). In the knowledge survey clinicians correctly determined familial risk in 55% and preventive measures in 65% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Currently 67% of individuals with an increased familial risk of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> were referred for preventive measures. Only one\u2010third were referred in accordance with guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12117","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T17:22:07Z","timestamp":1362244927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Familial colorectal cancer risk assessment needs improvement for more effective cancer prevention in relatives"],"prefix":"10.1111","volume":"15","author":[{"given":"N.","family":"Dekker","sequence":"first","affiliation":[{"name":"Scientific Institute for Quality of Healthcare Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"},{"name":"Department of Human Genetics Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P. M. 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