{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:43:02Z","timestamp":1768477382237,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients with hereditary non\u2010polyposis colorectal cancer (<jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content>) seem to have a better prognosis than those with sporadic colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>). The aim was to compare survival after Stage <jats:styled-content style=\"fixed-case\">III CC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content> with those having sporadic <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 230 patients with hereditary cancer from the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anish <jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content> Register and 3557 patients with sporadic <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> from the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anish <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>olorectal <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ancer <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>atabase, diagnosed during <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2001\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2008, were included. <jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content> patients were classified according to mismatch repair mutation status and family pedigree. Sporadic cases had no known family history of cancer. Patient characteristics, geographical differences and survival data were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was better in <jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content> patients compared with sporadic <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> after stratification for sex and age (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.04\u20131.7). The 5\u2010year survival was 70% in <jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content> patients compared with 56% in sporadic <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). No survival difference was found between <jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content> subgroups but a tendency to better <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was seen in patients with <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ynch syndrome. No geographical differences in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> were found. The median follow\u2010up was 3.9 (0\u20139.5) years for <jats:styled-content style=\"fixed-case\">HNPCC <\/jats:styled-content><jats:italic>vs<\/jats:italic> 3.2 (0\u20139.6) years for sporadic <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content> patients with Stage <jats:styled-content style=\"fixed-case\">III CC<\/jats:styled-content> have a better <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> compared with sporadic <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>. No significant difference in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was found within <jats:styled-content style=\"fixed-case\">HNPCC<\/jats:styled-content> subgroups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12150","type":"journal-article","created":{"date-parts":[[2013,1,26]],"date-time":"2013-01-26T09:35:49Z","timestamp":1359192949000},"page":"816-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Survival of patients with <scp>S<\/scp>tage <scp>III<\/scp> colon cancer is improved in hereditary non\u2010polyposis colorectal cancer compared with sporadic cases. A <scp>D<\/scp>anish registry based study"],"prefix":"10.1111","volume":"15","author":[{"given":"L. 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