{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:25:33Z","timestamp":1761823533765,"version":"3.40.3"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Inguinal nodes may be a possible route for lymphatic spread in patients with distal rectal cancer. The outcome was examined for patients with distal rectal cancer undergoing neoadjuvant chemoradiation (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) and having 2\u2010fluorine\u201018\u2010fluoro\u20102\u2010deoxy\u2010<jats:sc>d<\/jats:sc>\u2010glucose (<jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>)\u2010avid inguinal nodes using positron emission tomography\/computed tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Ninety\u2010nine consecutive patients with <jats:styled-content style=\"fixed-case\">cT<\/jats:styled-content>2\u20104N0\u20102M0 distal rectal adenocarcinoma were enrolled in a clinical trial (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>00254683) and underwent baseline <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> followed by 54\u00a0Gy and 5\u2010fluorouracil\u2010based <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>. After <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>, patients underwent 6\u2010 and 12\u2010week <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. Patients with positive inguinal node uptake were compared with patients with negative uptake. The inguinal region was not included in the field of radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen (17%) patients had baseline positive inguinal node <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content> uptake. They were more likely to have the tumour closer to the anal verge (2.0 <jats:italic>vs<\/jats:italic> 4.2\u00a0cm; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Of these, eight (47%) demonstrated a positive inguinal uptake at <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> after 12\u00a0weeks from <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>. Patients with inguinal node <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content> uptake after <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> (positive <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> at baseline and 12\u00a0weeks) had a significantly worse 3\u2010year overall and disease\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). After a median follow\u2010up period of 22\u00a0months, none of these patients had developed inguinal recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Uptake of inguinal nodes at <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> may be present in up to 17% of patients with distal rectal cancer, particularly with ultra\u2010low tumours. Nearly half of these nodes no longer show uptake after <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> despite the groin area not being included in the radiation field. Persistence of inguinal node uptake 12\u00a0weeks after <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> completion may be a marker for worse oncological outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12159","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T20:14:05Z","timestamp":1359749645000},"page":"674-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical relevance of positron emission tomography\/computed tomography\u2010positive inguinal nodes in rectal cancer after neoadjuvant chemoradiation"],"prefix":"10.1111","volume":"15","author":[{"given":"R. O.","family":"Perez","sequence":"first","affiliation":[{"name":"Angelita and Joaquim Gama Institute Sao Paulo Brazil"},{"name":"Department of Gastroenterology \u2013 Colorectal Surgery Division University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Habr\u2010Gama","sequence":"additional","affiliation":[{"name":"Angelita and Joaquim Gama Institute Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. P.","family":"S\u00e3o Juli\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology \u2013 Colorectal Surgery Division University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Proscurshim","sequence":"additional","affiliation":[{"name":"Angelita and Joaquim Gama Institute Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Radiology \u2013 Nuclear Medicine Division University of S\u00e3o Paulo School of Medicine Sao Paulo Brazil"},{"name":"Department of Radiology and Nuclear Medicine Hospital do Cora\u00e7\u00e3o Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lynn","sequence":"additional","affiliation":[{"name":"Angelita and Joaquim Gama Institute Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bail\u00e3o Aguilar","sequence":"additional","affiliation":[{"name":"Angelita and Joaquim Gama Institute Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Nahas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology \u2013 Colorectal Surgery Division University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gama\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"Angelita and Joaquim Gama Institute Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Buchpiguel","sequence":"additional","affiliation":[{"name":"Department of Radiology \u2013 Nuclear Medicine Division University of S\u00e3o Paulo School of Medicine Sao Paulo Brazil"},{"name":"Department of Radiology and Nuclear Medicine Hospital do Cora\u00e7\u00e3o Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.02134.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040694"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.08.070"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199903)70:3<177::AID-JSO6>3.0.CO;2-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80204-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02235048"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.01821.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9244-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26644"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181f42b89"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000141194.27992.32"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2396"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b91e63"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-010-0582-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-10"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.04.020"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12159","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T10:41:24Z","timestamp":1743936084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/codi.12159"],"URL":"https:\/\/doi.org\/10.1111\/codi.12159","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"type":"print","value":"1462-8910"},{"type":"electronic","value":"1463-1318"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"2012-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}