{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T23:26:38Z","timestamp":1774740398698,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study was carried out to clarify the clinical features of acute haemorrhagic rectal ulcer (<jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content>) and to determine the risks and predictors of <jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content> rebleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Forty patients with <jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content> were retrospectively analysed. Patient characteristics, endoscopic features and clinical course were investigated and predictors of <jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content> rebleeding were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were in a bedridden state as a result of various diseases, and many patients had atherosclerosis\u2010related comorbidities such as hypertension (67.4%), diabetes mellitus (40.0%) and chronic kidney disease (42.5%). All patients had hypoalbuminaemia, 75% of patients were using antithrombotic drugs and 25% of patients were using systemic corticosteroids. Based on colonoscopy, all patients developed ulcers in the distal rectum just above the dentate line and 30% of patients developed whole circumferential ulcers. The median interval between the onset of the bedridden state and the first massive haematochezia was 16\u00a0days and 50% of all patients developed rebleeding regardless of the presence or absence of haemostatic therapy. The median time from initial haemostasis to rebleeding was 6\u00a0days. Univariate analysis and stepwise multivariate analysis revealed that whole circumferential ulcer (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.036) was a significant independent predictor of <jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content> rebleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the present study, we elucidated the clinical features of <jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content> in detail and reviewed previous reports of <jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content>. Rebleeding of <jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content> occurred at a high rate and whole circumferential ulcer was a significant independent predictor of <jats:styled-content style=\"fixed-case\">AHRU<\/jats:styled-content> rebleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12162","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T20:14:06Z","timestamp":1359749646000},"page":"878-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical course and rebleeding predictors of acute haemorrhagic rectal ulcer: 5\u2010year experience and review of the literature"],"prefix":"10.1111","volume":"15","author":[{"given":"T.","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kobe City Medical Centre General Hospital Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Inokuma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kobe City Medical Centre General Hospital Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3862\/jcoloproctology.33.222"},{"key":"e_1_2_7_3_1","first-page":"1344","article-title":"Acute hemorrhagic rectal ulcer \u2013 special reference to its clinical findings","volume":"26","author":"Hirooka T","year":"1984","journal-title":"Gastroenterol Endosc"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0158-x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200109000-00012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1759-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0531-1"},{"key":"e_1_2_7_8_1","first-page":"1481","article-title":"Etiology of acute hemorrhagic rectal ulcer. Laser\u2010Doppler analysis of rectal mucosal blood flow in lateral and horizontal supine position at bed rest","volume":"38","author":"Nakamura S","year":"1996","journal-title":"Gastroenterol Endosc"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1886-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.02091.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2010.05.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.5.613"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.055202"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/000313480907500114","article-title":"Risk factors and management for massive bleeding of of an acute hemorrhagic rectal ulcer","volume":"75","author":"Hotta T","year":"2009","journal-title":"Am Surg"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12162","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:09:17Z","timestamp":1696367357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/codi.12162"],"URL":"https:\/\/doi.org\/10.1111\/codi.12162","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"2012-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}