{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:17:44Z","timestamp":1787235464364,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Diaphragmatic disease is rare. This review aims to increase awareness of this condition and its management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A literature search was conducted using the key terms \u2018colon\u2019 or \u2018colonic\u2019 in combination with \u2018diaphragm\u2019 or \u2018diaphragm disease\u2019 for publications until August 2012. All cases of colonic diaphragm syndrome were identified and the required data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010five cases of colon diaphragm disease were included. The highest incidence was in the seventh decade of life, with a female preponderance (40F:5M). Most patients presented with chronic (median 3\u00a0months) and multiple symptoms. The median use of nonsteroidal anti\u2010inflammatory drugs (\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s) was 5\u00a0years including diclofenac as the most commonly used\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      . Colonoscopy was the most informative investigation and the ascending colon was the most common site of diaphragm disease. Nearly two\u2010thirds of the patients were treated by discontinuing\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      treatment combined with other forms of treatment, mostly surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Diaphragm disease of the colon is a rare condition associated with long\u2010term use of\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s with a range of presentations and symptoms. Based on this review, when colon diaphragm disease is diagnosed we would recommend a trial cessation of\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s. Therapeutic endoscopic techniques should be considered but surgery may be required for definitive treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.12218","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T04:39:46Z","timestamp":1363840786000},"page":"1063-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Diaphragmatic disease of the colon: systematic review"],"prefix":"10.1111","volume":"15","author":[{"given":"P. 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