{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:05:23Z","timestamp":1760346323651},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Minimal data are available on the role of pelvic exenteration in patients with recurrent squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) of the pelvic organs. This study aimed to highlight our experience of pelvic exenteration in patients with recurrent and re\u2010recurrent <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the pelvic organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective review of all patients who underwent pelvic exenteration for recurrent <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the pelvic organs arising from the embryological cloaca from 1994 to 2010 was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients (median age 59, range, 27\u201379\u00a0years) underwent pelvic exenteration for recurrent <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the anus (18), cervix and upper vagina (2), lower vagina (1) and the vulva (3). Nine patients with anal <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> had undergone abdominoperineal excision prior to pelvic exenteration. Ten (41.7%) patients underwent a complete pelvic exenteration procedure, while sacrectomy was performed in 13 (54.2%) patients. There was no 30\u2010day inpatient mortality. An R0 resection was achieved in 15 (62.5%) patients. Three (12.5%) had R1 resections while 6 (25%) had R2 resections. In the 15 patients with an R0 resection, 7 (46.7%) developed metastatic disease at a median of 18 (range 10\u2013131) months. After a median follow\u2010up of 26 (range 4\u2013169) months, 1\u2010 and 2\u2010year overall survival rates were 64% [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 44\u201384%] and 57% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 35\u201379%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pelvic exenteration for recurrent <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the cloaca is safe and feasible even after previous salvage surgery. An R0 resection can be achieved in 62.5% of the patients with reasonable early survival though less than published recurrent rectal cancer studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12306","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T07:42:16Z","timestamp":1369813336000},"page":"1227-1231","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pelvic exenteration for recurrent squamous cell carcinoma of the pelvic organs arising from the cloaca \u2013 a single institution's experience over 16\u00a0years"],"prefix":"10.1111","volume":"15","author":[{"given":"K. K.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rodwell","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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