{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T15:52:56Z","timestamp":1719762776302},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study assessed the impact on anorectal function of endoscopic mucosal resection (<jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>) and transanal endoscopic microsurgery (<jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>) of large rectal adenomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with a large (\u2265\u00a03\u00a0cm) rectal adenoma undergoing <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> were included. Self\u2010reported faecal incontinence was assessed using the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>olorectal <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>unctional <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>utcome (<jats:styled-content style=\"fixed-case\">COREFO<\/jats:styled-content>) questionnaire and the <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>exner <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ncontinence <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rading <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale. Anorectal manometry was performed before and at 6\u00a0months after treatment to measure anal resting (<jats:styled-content style=\"fixed-case\">ARP<\/jats:styled-content>) and squeeze pressure (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>), squeeze endurance (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>), the rectoanal inhibitory reflex (<jats:styled-content style=\"fixed-case\">RAIR<\/jats:styled-content>), rectal volumetry of first sensation (<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>), first urge (<jats:styled-content style=\"fixed-case\">FU<\/jats:styled-content>), maximum tolerable volume (<jats:styled-content style=\"fixed-case\">MTV<\/jats:styled-content>) and rectal compliance (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients were included in the study, of whom 11 underwent EMR and 13 underwent TEM. The mean adenoma size was 51\u00a0\u00b1\u00a019\u00a0mm and the median distance from the anal verge was 3\u00a0cm (interquartile range 1\u201310\u00a0cm). Follow\u2010up data were available from 20 patients; one patient had died and three had undergone total mesorectal excision. Incontinence for liquid stool and <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>exner score decreased significantly after treatment. In contrast, none of the measured parameters of anorectal motility (<jats:styled-content style=\"fixed-case\">ARP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RAIR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RC<\/jats:styled-content>) and perception (<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FU<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MTV<\/jats:styled-content>) was affected by adenoma resection. No differences were found in baseline and follow\u2010up incontinence and functional parameters between intervention groups, except for postprocedural <jats:styled-content style=\"fixed-case\">ARP<\/jats:styled-content>, which was lower after <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> than after <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Continence in patients with a large rectal adenoma improved after <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>, probably due to decreased rectal mucus production. Anal sphincter pressure, rectoanal reflexes, rectal sensation and compliance were not affected by adenoma resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12311","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T05:57:06Z","timestamp":1370843826000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of endoscopic mucosal resection and transanal endoscopic microsurgery on anorectal function"],"prefix":"10.1111","volume":"15","author":[{"given":"R. M.","family":"Barendse","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Oors","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J. R.","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Surgery IJsselland Hospital Capelle aan den Ijssel The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. A.","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Fockens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. P. M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90273-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.5.675"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308412"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003840100325"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-9-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256765"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7584"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02081411"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1996.02082.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6252-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0475-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-004-0638-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00298538"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.6.807"},{"key":"e_1_2_7_17_1","first-page":"99","article-title":"Manometric evaluation of defecation disorders: Part II. Fecal incontinence","volume":"5","author":"Rao SS","year":"1997","journal-title":"Gastroenterologist"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00950.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800811143"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296139"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:02:30Z","timestamp":1696320150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/codi.12311"],"URL":"https:\/\/doi.org\/10.1111\/codi.12311","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"2012-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}