{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:21:45Z","timestamp":1791926505862,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The hypothesis was tested that evoked pressure curves (<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s) after transcranial magnetic stimulation (<jats:styled-content style=\"fixed-case\">TMS<\/jats:styled-content>) would provide additional neuropathophysiological information on the descending pathways to the external anal sphincter (<jats:styled-content style=\"fixed-case\">EAS<\/jats:styled-content>) in patients with faecal incontinence (<jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty\u2010five healthy subjects and 69 patients with <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> were investigated. <jats:styled-content style=\"fixed-case\">TMS<\/jats:styled-content> was applied to the vertex, and <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s were recorded with a probe placed through the <jats:styled-content style=\"fixed-case\">EAS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">TMS<\/jats:styled-content> was performed with the <jats:styled-content style=\"fixed-case\">EAS<\/jats:styled-content> at rest and during contraction (facilitated responses). At least three responses were recorded for each modality. Clinical data and anorectal manometric, electrophysiological perineal and transanal ultrasound recordings were compared with respect to the <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistically significant difference between the <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s of healthy subjects and <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> patients. Twenty\u2010three per cent of the <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> patients had abnormal <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> latencies, with significantly lower voluntary contraction amplitudes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and significantly higher rectal sensation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) than the other group. We found no significant difference between <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> patients with and without abnormal <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> latencies in terms of clinical characteristics and electrophysiological and endoanal ultrasound parameters. There was no difference in the identified causes of the <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As abnormal <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> latencies were found in 23% of <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> patients with no known central neurological disease, abnormal <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> latencies might reveal undetected lesions of descending pathways in patients with <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12386","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T09:04:37Z","timestamp":1376903077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evoked pressure curves from the external anal sphincter following transcranial magnetic stimulation in healthy volunteers and patients with faecal incontinence"],"prefix":"10.1111","volume":"15","author":[{"given":"G.","family":"Paris","sequence":"first","affiliation":[{"name":"INSERM U1073, CIC Rouen University Hospital, F\u201076031 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Chastan","sequence":"additional","affiliation":[{"name":"INSERM U1073, CIC Rouen University Hospital, F\u201076031 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gourcerol","sequence":"additional","affiliation":[{"name":"INSERM U1073, CIC Rouen University Hospital, F\u201076031 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Verin","sequence":"additional","affiliation":[{"name":"Ventilatory Handicap Research Group UPRES EA 3830\/IFRMP23 Rouen University Hospital, F\u201076031 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Menard","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Rouen University Hospital, F\u201076031 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Michot","sequence":"additional","affiliation":[{"name":"INSERM U1073, CIC Rouen University Hospital, F\u201076031 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Weber","sequence":"additional","affiliation":[{"name":"INSERM U1073, CIC Rouen University Hospital, F\u201076031 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Leroi","sequence":"additional","affiliation":[{"name":"INSERM U1073, CIC Rouen University Hospital, F\u201076031 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb03053.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1997.d01-2.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.6.771"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20387"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(89)90056-7"},{"key":"e_1_2_8_7_1","first-page":"G720","article-title":"Quantification of motor pathways to the pelvic floor in humans","volume":"260","author":"Herdmann J","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292249"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)05388-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237361"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(00)00222-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234288"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6329-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20066"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(90)90137-9"},{"key":"e_1_2_8_16_1","first-page":"G225","article-title":"Speed and pressure characteristics of external anal sphincter contractions","volume":"269","author":"Herdmann J","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)31670-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236932"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0746-4"},{"key":"e_1_2_8_21_1","first-page":"371","article-title":"The 10\u201020 electrode system of the International Federation","volume":"10","author":"Jasper HH","year":"1958","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.10.014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90037-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.478"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:21:15Z","timestamp":1696303275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,21]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/codi.12386"],"URL":"https:\/\/doi.org\/10.1111\/codi.12386","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,21]]},"assertion":[{"value":"2013-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}