{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T14:52:07Z","timestamp":1766587927633},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Currently only 12\u201330% of individuals with a high risk of Lynch syndrome, the most common hereditary colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) syndrome, are referred for genetic counselling. We assessed the sensitivity, usability and user experiences of a new online referral test aimed at improving referral of high\u2010risk individuals for genetic counselling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sensitivity was assessed by entering pedigree data from high\u2010risk individuals (i.e. Lynch syndrome mutation carriers) into the referral test to determine whether genetic counselling was recommended. For usability, we assessed nonmedical staff members' ability to determine referral, according to guidelines, in seven fictive clinical cases using the referral test after minimal training. Real\u2010life users answered questions about their experience with the referral test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Sensitivity of the referral test was 91% for mutation carriers with <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>164) and 73% for all affected and nonaffected mutation carriers (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>420). Nonmedical staff members (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>20) determined referral according to guidelines in 84% of cases using the referral test. Ten per cent (256\/2470) of real\u2010life users provided feedback about experiences; of those, 71% reported that the referral test increased reassurance, certainty about their familial risk and\/or certainty about referral.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The referral test has a high sensitivity in detecting individuals with a high risk of Lynch syndrome and is suitable for use in clinical practice. Widespread use of the referral test should improve cancer prevention in high\u2010risk patients and their relatives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12407","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T07:49:48Z","timestamp":1377589788000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Easy\u2010to\u2010use online referral test detects most patients with a high familial risk of colorectal cancer"],"prefix":"10.1111","volume":"16","author":[{"given":"N.","family":"Dekker","sequence":"first","affiliation":[{"name":"Scientific Institute for Quality of Healthcare Radboud University Nijmegen Medical Centre Nijmegen the Netherlands"},{"name":"Department of Human Genetics Radboud University Nijmegen Medical Centre Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P. M. 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