{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:38:06Z","timestamp":1696343886838},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Lower gastrointestinal (<jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>) symptoms are prevalent in patients screened for bowel cancer yet do not predict a finding of cancer. This study evaluates symptoms in patients with these characteristics against the 2\u2010week wait (2ww) criteria to determine whether they predicted cancer in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A prospective cohort study was performed. Patients with a positive faecal occult blood (<jats:styled-content style=\"fixed-case\">FOB<\/jats:styled-content>) test attending our unit over a 7\u2010month period were included. Data on symptom prevalence, frequency and duration were collected and assessed against the 2ww criteria. Associations between symptom prevalence and patient outcome were investigated using the \u03c7<jats:sup>2<\/jats:sup> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and ninety\u2010seven patients were included and 37 (9%) were found to have colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>). The prevalence of undefined <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> symptoms was 71% and appeared comparable between those with and without <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> (65 <jats:italic>vs<\/jats:italic> 72%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.385). 2ww symptoms were reported in 147 (37%), with 2ww change in bowel habit in 10% and 2ww rectal bleeding in 31%. 2ww symptom prevalence was similar in those with and without cancer (38 <jats:italic>vs<\/jats:italic> 37%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.915). No significant differences in overall 2ww prevalence or prevalence of individual 2ww symptoms were demonstrated between those with a normal colonoscopy or one showing cancer, polyps or other pathology. Twenty nine per cent of patients with 2ww symptoms had reported these to their <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Undefined <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> symptoms are prevalent in <jats:styled-content style=\"fixed-case\">FOB<\/jats:styled-content>\u2010positive patients but do not predict <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>. 2ww symptoms are also highly prevalent, yet similarly fail to predict cancer. Further efforts to increase public awareness of cancer symptoms are required, whilst false reassurance from a negative <jats:styled-content style=\"fixed-case\">FOB<\/jats:styled-content> result should be discouraged.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12422","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:28:55Z","timestamp":1381249735000},"page":"40-47","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Two\u2010week wait symptoms are prevalent in screened patients with a positive faecal occult blood test but do not predict cancer"],"prefix":"10.1111","volume":"16","author":[{"given":"P. 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